{"id":"W4405040849","doi":"10.1182/blood-2024-198979","title":"Dose Optimization of Check-Point Inhibitors: A Comparison of Standard Dose and Low Dose Nivolumab in Relapsed/Refractory Hodgkin Lymphoma","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Nivolumab; Medicine; Refractory (planetary science); Lymphoma; Nuclear medicine; Hodgkin lymphoma; Oncology; Internal medicine; Immunotherapy; Cancer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001479163,0.000228396,0.0007993985,0.0003385333,0.0001273772,0.0006971669,0.0004778748,0.0004040574,0.001206394],"category_scores_gemma":[0.002412296,0.0001279579,0.001239327,0.000340903,0.0003890525,0.0005222751,0.0002757146,0.0008623037,0.0001683417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001153217,"about_ca_system_score_gemma":0.0004769826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004558051,"about_ca_topic_score_gemma":0.0007773141,"domain_scores_codex":[0.9989666,0.0005282254,0.0001168084,0.0001556152,0.0001495422,0.00008317736],"domain_scores_gemma":[0.9988681,0.000404852,0.0004152981,0.00008164465,0.00006828039,0.0001618739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5320224,0.009353624,0.1049302,0.001692615,0.004553261,0.0002038781,0.00030628,0.006693383,0.0134156,0.0004407657,0.001194438,0.3251937],"study_design_scores_gemma":[0.06059216,0.5756534,0.3286191,0.0005314769,0.006595484,0.001112452,0.0004027588,0.008793899,0.008906223,0.0007757828,0.007926766,0.00009053146],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947171,0.00403444,0.0003068892,0.00007866907,0.00003310915,0.000135847,0.0001139911,0.000008835942,0.0005711475],"genre_scores_gemma":[0.998782,0.0005451367,0.0002559914,0.00008727903,0.00002734854,0.00005928268,0.000137708,0.000003110138,0.000102008],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001479163,"threshold_uncertainty_score":0.008367181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01215391054027403,"score_gpt":0.2723099036470323,"score_spread":0.2601559931067582,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}