{"id":"W4405040852","doi":"10.1182/blood-2024-206495","title":"HPK1 Inhibition and Venetoclax Combination Suppressed AML By Enhancing Cytotoxic T-Cell Response to Leukaemia","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Venetoclax; Cytotoxic T cell; Cancer research; Leukemia; Medicine; Oncology; Internal medicine; Biology; Genetics; Chronic lymphocytic leukemia; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008498697,0.0003178107,0.0004028843,0.0002056247,0.0001267102,0.000205215,0.000228401,0.0001411193,0.001822262],"category_scores_gemma":[0.0001015766,0.00007826462,0.0001566511,0.0001538086,0.000191745,0.0001504721,0.0001417324,0.000795854,0.0002853598],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000182387,"about_ca_system_score_gemma":0.0002398906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003728166,"about_ca_topic_score_gemma":0.0006786366,"domain_scores_codex":[0.999933,0.00001035707,0.000005940839,0.00001005154,0.00001231346,0.00002838822],"domain_scores_gemma":[0.9999461,0.000008919801,0.00001249291,0.000006969794,0.000003999917,0.00002147782],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006753874,0.001298243,0.001249646,0.0003096609,0.00004630462,0.0001916191,0.00008644013,0.0009733808,0.9556198,0.0003326663,0.001046755,0.03209164],"study_design_scores_gemma":[0.000880982,0.01465487,0.0129681,0.0000270846,0.0001146791,0.0008985819,0.00004709672,0.002308326,0.959526,0.0001382459,0.008418577,0.00001738424],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961106,0.001668531,0.0003329087,0.00007935886,0.00004981177,0.00003870686,0.0001926142,0.0001114676,0.001416019],"genre_scores_gemma":[0.9972971,0.0007767631,0.000352399,0.00002993949,0.00002358037,0.00003312684,0.0003069477,0.000006790277,0.001173428],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001822262,"threshold_uncertainty_score":0.006096065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003815161177408138,"score_gpt":0.231267887583916,"score_spread":0.2274527264065079,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}