{"id":"W4405040880","doi":"10.1182/blood-2024-201710","title":"Combination of Olutasidenib and Azacitidine Induces Durable Complete Remissions in m<i>IDH1</i> Acute Myeloid Leukemia: A Multicohort Open-Label Phase 1/2 Trial","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Azacitidine; Myeloid leukemia; Medicine; Internal medicine; Open label; Leukemia; Phases of clinical research; Oncology; Cancer research; Clinical trial; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002735793,0.001367684,0.002225278,0.0004893913,0.0004871466,0.0011735,0.0007757997,0.001199582,0.004040993],"category_scores_gemma":[0.0009914567,0.0006327044,0.001805828,0.0005236604,0.0007471449,0.0008992935,0.0004406796,0.002713619,0.0007905723],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007828842,"about_ca_system_score_gemma":0.001174498,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005224902,"about_ca_topic_score_gemma":0.002139725,"domain_scores_codex":[0.9992422,0.000407617,0.00005157646,0.0001259513,0.00007253539,0.0001001386],"domain_scores_gemma":[0.99927,0.0001134151,0.0001804164,0.00007752601,0.00005344382,0.0003050714],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8848951,0.02969401,0.003312794,0.0009680507,0.003224808,0.0001134838,0.000153647,0.0008534443,0.01754001,0.0001291099,0.002853533,0.05626213],"study_design_scores_gemma":[0.7875114,0.1993502,0.007692716,0.00004312013,0.001232923,0.0001588144,0.00003752857,0.000505968,0.001537704,0.0001217284,0.001780702,0.00002707354],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876307,0.004963012,0.0004822946,0.0005310037,0.0001848675,0.002993793,0.001341796,0.0001398511,0.001732772],"genre_scores_gemma":[0.9879434,0.003073342,0.00153816,0.0008282477,0.0003049977,0.002388614,0.001861223,0.00003154507,0.002030499],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004040993,"threshold_uncertainty_score":0.01446843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06387992848415537,"score_gpt":0.3703111879506398,"score_spread":0.3064312594664844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}