{"id":"W4405040905","doi":"10.1182/blood-2024-209286","title":"Comprehensive Characterization of the Plasma Proteome of Multiple Myeloma and Its Precursor Conditions and Identification of a Proteomic Signature to Improve Risk Prediction of Disease Progression","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"Monoclonal gammopathy of undetermined significance; Multiple myeloma; Proteome; Disease; Medicine; Oncology; Computational biology; Biology; Internal medicine; Immunology; Cancer research; Antibody; Bioinformatics; Monoclonal; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003540271,0.000251079,0.0003462162,0.0005025357,0.0001987411,0.0004382937,0.0001251945,0.0002255105,0.0009250917],"category_scores_gemma":[0.0003525908,0.00009625787,0.000297508,0.0007055592,0.0001018612,0.0002252099,0.0003102208,0.0002312486,0.0002646322],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001421312,"about_ca_system_score_gemma":0.0001926642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006468238,"about_ca_topic_score_gemma":0.0006762774,"domain_scores_codex":[0.9998531,0.00002064335,0.00001124484,0.00005571934,0.00003805527,0.00002122062],"domain_scores_gemma":[0.9998798,0.00003200291,0.0000405805,0.00001000597,0.00001993122,0.00001770557],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0007590861,0.00008671181,0.1295156,0.0002911847,0.0001564061,0.0002222133,0.0001472366,0.0008893082,0.826418,0.0001424793,0.0005066117,0.04086519],"study_design_scores_gemma":[0.00002059027,0.0006907351,0.8756056,0.00003109569,0.000147806,0.001426658,0.0001724456,0.005311502,0.1131691,0.0004179577,0.002988891,0.00001760115],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913053,0.001824444,0.004176361,0.00007298378,0.000008032408,0.00001987077,0.00202246,0.00007222367,0.0004981998],"genre_scores_gemma":[0.9870608,0.0009417938,0.008569636,0.00007160523,0.00001512372,0.00003675678,0.002606689,0.00001359108,0.0006839823],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009250917,"threshold_uncertainty_score":0.003094733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01168822211866729,"score_gpt":0.2752535996221905,"score_spread":0.2635653775035233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}