{"id":"W4405041194","doi":"10.1182/blood-2024-205936","title":"Targeting the SWI/SNF Chromatin Remodeling Complex Subunit SMARCA4 in ALL","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"SMARCA4; SWI/SNF; Chromatin remodeling; Protein subunit; Chromatin; Biology; Cell biology; Medicine; Chemistry; Cancer research; Genetics; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001249918,0.0004655911,0.0006358205,0.0008864964,0.0001790689,0.0006856537,0.000444089,0.0005203799,0.001322544],"category_scores_gemma":[0.001347537,0.0002360158,0.0007090366,0.0008814197,0.0003193552,0.0003412409,0.0004735913,0.0005156504,0.0002982611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000716487,"about_ca_system_score_gemma":0.0005111957,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005797026,"about_ca_topic_score_gemma":0.0009615481,"domain_scores_codex":[0.9996328,0.00009363476,0.00003120142,0.00008843063,0.00009518061,0.00005861782],"domain_scores_gemma":[0.9994792,0.0001868425,0.0001541838,0.00005351663,0.00006456372,0.00006171298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007177281,0.0002858314,0.2384189,0.002989651,0.004641551,0.001079653,0.0001983822,0.00866364,0.5159277,0.001507549,0.004502256,0.2146077],"study_design_scores_gemma":[0.001581593,0.00530233,0.3988973,0.0008738501,0.01220686,0.008789712,0.0004791766,0.01475765,0.4251905,0.00774277,0.1240708,0.000107478],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9356636,0.05357823,0.004849397,0.001142435,0.0001115116,0.00007121445,0.002362411,0.0002468041,0.001974356],"genre_scores_gemma":[0.9841012,0.01040844,0.002212766,0.0004681113,0.00004561549,0.0000563462,0.002271767,0.00004153061,0.0003941825],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001322544,"threshold_uncertainty_score":0.006610334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02913156476740118,"score_gpt":0.2831570278677704,"score_spread":0.2540254631003692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}