{"id":"W4405041412","doi":"10.1182/blood-2024-202069","title":"Intensive Chemotherapy Vs. Azacitidine + Venetoclax for AML with Secondary Mutations","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Venetoclax; Azacitidine; Chemotherapy regimen; Medicine; Internal medicine; Chemotherapy; Oncology; Leukemia; Genetics; Biology; Chronic lymphocytic leukemia; DNA methylation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005600082,0.000199683,0.0007313761,0.0002848037,0.0001633405,0.0004747717,0.0002743312,0.0003878984,0.002628864],"category_scores_gemma":[0.0007635018,0.0000723597,0.0006999883,0.0002346165,0.0002699765,0.0003175814,0.0002995618,0.0008691289,0.0002074981],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005354161,"about_ca_system_score_gemma":0.0004942665,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004635051,"about_ca_topic_score_gemma":0.001564342,"domain_scores_codex":[0.9996525,0.0001401481,0.00003131006,0.00007428757,0.00003522867,0.00006645126],"domain_scores_gemma":[0.9991861,0.0003425466,0.0001574357,0.00003983419,0.0000220275,0.0002519537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6987137,0.00628399,0.04344538,0.001138334,0.001854453,0.0002719166,0.0001635692,0.002995377,0.005879605,0.001127341,0.001780547,0.2363458],"study_design_scores_gemma":[0.09539729,0.6247301,0.2373412,0.001016913,0.004931259,0.001320939,0.0003279955,0.005705845,0.006607746,0.002788661,0.01976369,0.00006846948],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866415,0.009006736,0.0002422996,0.0002150038,0.0001706873,0.0003129427,0.0003341699,0.00001359014,0.003063117],"genre_scores_gemma":[0.9958209,0.001902574,0.0003645805,0.0003166541,0.0002795699,0.0002176139,0.0003989027,0.000003101799,0.0006961244],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002628864,"threshold_uncertainty_score":0.008794427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01533386673516579,"score_gpt":0.2955157901546872,"score_spread":0.2801819234195214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}