{"id":"W4405041836","doi":"10.1182/blood-2024-212294","title":"Timing Antigenic Escape in Multiple Myeloma Treated with T-Cell Redirecting Immunotherapies","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Multiple myeloma; Antigen; Immunology; Immunotherapy; Daratumumab; Medicine; Biology; Virology; Cancer research; Bortezomib; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006660952,0.0004006796,0.0006224621,0.0009300937,0.0003330628,0.0009580965,0.0005254646,0.0005109688,0.001512499],"category_scores_gemma":[0.0009930052,0.0002592947,0.000546397,0.001193095,0.0002901581,0.0003298947,0.0006435792,0.0005134306,0.0004942351],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008201782,"about_ca_system_score_gemma":0.0006562824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00372542,"about_ca_topic_score_gemma":0.007068696,"domain_scores_codex":[0.9995492,0.00004599581,0.00002333721,0.0001888654,0.0001379195,0.0000546737],"domain_scores_gemma":[0.9997604,0.00005619159,0.00007256934,0.00002292599,0.00005587658,0.00003191668],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002113146,0.0003391427,0.2830599,0.0007947736,0.0006185457,0.001052473,0.000647505,0.06125429,0.4283163,0.002715676,0.005791207,0.2132971],"study_design_scores_gemma":[0.0001212074,0.001127516,0.2835385,0.0001354172,0.0004227084,0.002015182,0.0007475872,0.4136156,0.2664512,0.00906573,0.022627,0.0001323486],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9434536,0.002137574,0.04481822,0.0002935052,0.00005637853,0.000127932,0.005095127,0.001873723,0.002143986],"genre_scores_gemma":[0.9193886,0.000754085,0.07270208,0.0001816056,0.00001816015,0.0001146977,0.005600211,0.0003591507,0.0008814394],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00372542,"threshold_uncertainty_score":0.007407427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02571826290794195,"score_gpt":0.2762986199602764,"score_spread":0.2505803570523344,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}