{"id":"W4405041866","doi":"10.1016/j.biopha.2024.117717","title":"N-Phenyl ureidobenzenesulfonates, a novel class of human dihydroorotate dehydrogenase inhibitors inducing differentiation and apoptosis in acute myeloid leukemia cells","year":2024,"lang":"en","type":"article","venue":"Biomedicine & Pharmacotherapy","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier de l'Université Laval; Hôpital Saint-François d'Assise","funders":"","keywords":"Dihydroorotate dehydrogenase; Myeloid leukemia; Leukemia; Apoptosis; Myeloid; Cancer research; Myeloid cells; Immunology; Chemistry; Biology; Medicine; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002538472,0.0002502566,0.0002583202,0.0002543598,0.00004906156,0.00002872845,0.0001728529,0.0001849871,0.00003105949],"category_scores_gemma":[0.000007605746,0.0002111222,0.00009765777,0.0003868329,0.0001706056,0.00000984581,0.00009790553,0.0002214004,0.00000203333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005981355,"about_ca_system_score_gemma":0.0000983525,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001760472,"about_ca_topic_score_gemma":0.00001204245,"domain_scores_codex":[0.9984137,0.00005348311,0.0003909648,0.00053052,0.0002740635,0.0003373099],"domain_scores_gemma":[0.9995037,0.00001673127,0.00007222185,0.0002019242,0.00004920003,0.0001562181],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001276367,0.0001053334,0.0002198822,0.0001595569,0.0001939071,0.000008993588,0.0001457676,0.00000400962,0.9893009,0.00002430738,0.0007199966,0.008989689],"study_design_scores_gemma":[0.002057997,0.0003283525,0.0002192248,0.0001542252,0.0000492545,0.000009598399,0.00002072692,0.0007003536,0.9900102,0.00003412033,0.006196938,0.0002190091],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930238,0.00552069,0.0004767823,0.0003065635,0.000200101,0.0003440058,0.00005024639,0.00002441023,0.00005344803],"genre_scores_gemma":[0.9960883,0.002768925,0.000120581,0.000284885,0.0002730535,0.00004422458,0.0002075539,0.00005030381,0.0001621316],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008770679,"threshold_uncertainty_score":0.8609312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01309285821507667,"score_gpt":0.3021379242801419,"score_spread":0.2890450660650652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}