{"id":"W4405041895","doi":"10.1182/blood-2024-203618","title":"Investigating the Metabolic Underpinnings of Venetoclax Resistance in DLBCL","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Gilead Sciences; AstraZeneca; Incyte; Amgen","keywords":"Venetoclax; Ibrutinib; Medicine; Internal medicine; Oncology; Leukemia; Chronic lymphocytic leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000124254,0.0001877011,0.0001573269,0.0002859135,0.0001468545,0.0002807458,0.0001995074,0.0002774638,0.0009673241],"category_scores_gemma":[0.0001224184,0.00009199011,0.0001396884,0.0003304878,0.0001692711,0.0002251785,0.0001686939,0.00044165,0.0001456597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003658271,"about_ca_system_score_gemma":0.0001114446,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007075628,"about_ca_topic_score_gemma":0.0009431918,"domain_scores_codex":[0.9999268,0.00001251063,0.000005686974,0.00001796274,0.0000236035,0.00001338813],"domain_scores_gemma":[0.9999201,0.00001639729,0.00002944984,0.00000919696,0.00001233792,0.00001241095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001489416,0.00003428655,0.00180572,0.00004410085,0.000006347219,0.00003532623,0.00002040472,0.0001076296,0.9954494,0.00004104325,0.00002035691,0.002286631],"study_design_scores_gemma":[0.00002750084,0.001106857,0.04358586,0.00001152703,0.00004728687,0.0008249908,0.0001012863,0.001651101,0.94958,0.0001329454,0.002922154,0.000008489996],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958957,0.001531526,0.001395459,0.00007789153,0.000006678934,0.00003029508,0.0004104774,0.00003414281,0.0006178251],"genre_scores_gemma":[0.9945209,0.00118146,0.002591606,0.00005259953,0.000006030666,0.00003061369,0.0008616904,0.00001033485,0.0007447707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009673241,"threshold_uncertainty_score":0.003235996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02608518767290764,"score_gpt":0.3100039948614766,"score_spread":0.2839188071885689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}