{"id":"W4405042012","doi":"10.1182/blood-2024-209597","title":"Phase II Study of Isatuximab, and Weekly Carfilzomib + Dexamethasone in Relapsed and Refractory Multiple Myeloma (RRMM)","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Carfilzomib; Multiple myeloma; Lenalidomide; Medicine; Oncology; Internal medicine; Dexamethasone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002249142,0.001947102,0.002907587,0.0006202964,0.0006161086,0.001274729,0.001520262,0.001660124,0.004361722],"category_scores_gemma":[0.0009258228,0.0009449832,0.001301641,0.0006573554,0.001260525,0.000916443,0.0004331545,0.00437401,0.001424231],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001441256,"about_ca_system_score_gemma":0.002546799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001644658,"about_ca_topic_score_gemma":0.003275488,"domain_scores_codex":[0.9992854,0.0003252092,0.00003515893,0.0001235446,0.00008244169,0.0001483334],"domain_scores_gemma":[0.9988551,0.000120376,0.000170235,0.00009510401,0.00006882289,0.0006902827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6742541,0.193671,0.008516571,0.0007602894,0.001389348,0.0005127485,0.0004550431,0.002359903,0.04691717,0.0003088407,0.00365885,0.06719611],"study_design_scores_gemma":[0.5374505,0.4485615,0.007931693,0.00002265036,0.0002730812,0.0003194131,0.00004779727,0.0007612054,0.002421064,0.0001135041,0.002077832,0.00001985998],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987888,0.002207958,0.0007005003,0.0005578776,0.0002003269,0.005246533,0.001139964,0.0001213046,0.001937492],"genre_scores_gemma":[0.985827,0.001562575,0.001638921,0.0009287914,0.0002832178,0.004233823,0.002569243,0.00003377288,0.00292276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004361722,"threshold_uncertainty_score":0.0145914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03124142184940028,"score_gpt":0.3292639495267669,"score_spread":0.2980225276773666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}