{"id":"W4405042087","doi":"10.1182/blood-2024-206912","title":"A Phase 1b Study of Step-up Dosing with ABBV-383, a B-Cell Maturation Antigen (BCMA) x CD3 Bispecific Antibody, in Patients with Relapsed or Refractory Multiple Myeloma","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Bispecific antibody; Medicine; Multiple myeloma; Refractory (planetary science); Antibody; Antigen; Cancer research; Internal medicine; Immunology; Monoclonal antibody; Materials science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009418188,0.00119678,0.001274972,0.0004055266,0.0003687033,0.0007819828,0.0008198395,0.001127377,0.004604333],"category_scores_gemma":[0.0006106389,0.0005051618,0.0007967125,0.0003204779,0.0007150304,0.0006545905,0.0003092787,0.00284216,0.000922355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009973143,"about_ca_system_score_gemma":0.001683184,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001648093,"about_ca_topic_score_gemma":0.005062918,"domain_scores_codex":[0.9996887,0.0001268111,0.00001009063,0.00006847681,0.00003207558,0.00007382807],"domain_scores_gemma":[0.9995778,0.00005090554,0.0000642231,0.00003410837,0.00002821951,0.0002446931],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5228259,0.1861721,0.009065518,0.0007546889,0.001240343,0.0003449364,0.0005289612,0.003702698,0.11841,0.0006017461,0.008984257,0.1473688],"study_design_scores_gemma":[0.3607331,0.6163576,0.01186194,0.0000257373,0.0002667059,0.0002292609,0.00007102462,0.001407229,0.004736897,0.0003215367,0.003958341,0.00003071475],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912258,0.001110256,0.0005895499,0.0004475418,0.0001136207,0.002944663,0.00139324,0.000113204,0.002062079],"genre_scores_gemma":[0.9842264,0.001386842,0.002820883,0.001110308,0.0001177011,0.002898989,0.003179073,0.00004435773,0.004215383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004604333,"threshold_uncertainty_score":0.01540303,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02212039836126375,"score_gpt":0.3101483756464769,"score_spread":0.2880279772852131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}