{"id":"W4405042096","doi":"10.1182/blood-2024-197988","title":"Chemotherapy-Induced Bone Defects Stem from Skeletal Progenitor Dysfunction","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Management of metastatic bone disease","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; University of Toronto; Princess Margaret Cancer Centre; Ottawa Hospital; University Health Network","funders":"","keywords":"Stem cell; Progenitor cell; Medicine; Chemotherapy; Pathology; Cancer research; Biology; Internal medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001778967,0.000339634,0.0003377945,0.0005949254,0.000197708,0.0003727658,0.000184079,0.0003731028,0.002193433],"category_scores_gemma":[0.0001228499,0.0001970093,0.0003486523,0.000327729,0.0003178262,0.000207363,0.0003336956,0.0008961667,0.0003486191],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000223798,"about_ca_system_score_gemma":0.0002603534,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006418882,"about_ca_topic_score_gemma":0.00167694,"domain_scores_codex":[0.9997999,0.00001921647,0.00002011749,0.00003061718,0.0001049954,0.00002508119],"domain_scores_gemma":[0.9998806,0.00001892263,0.00004612775,0.00001344998,0.00001355326,0.00002732358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001823715,0.00008235878,0.00279553,0.0001613597,0.00002240449,0.0004295647,0.00005202726,0.0001828892,0.983941,0.0004497557,0.0002521631,0.01144845],"study_design_scores_gemma":[0.00009829416,0.002162878,0.1055307,0.00009654119,0.0001161806,0.004928273,0.0002530326,0.001878659,0.8667758,0.000703097,0.01743661,0.00002003603],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9765837,0.008789072,0.007184416,0.0003527507,0.00006364333,0.0001419087,0.001752853,0.0002550598,0.004876475],"genre_scores_gemma":[0.9891618,0.003372517,0.002558022,0.0002568067,0.000009102504,0.0001064564,0.001164276,0.00003136759,0.003339702],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002193433,"threshold_uncertainty_score":0.007337749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01684971440669886,"score_gpt":0.2541860513920383,"score_spread":0.2373363369853395,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}