{"id":"W4405042174","doi":"10.1182/blood-2024-200018","title":"Glofitamab Induces High Response Rates and Durable Remissions in Patients (Pts) with Heavily Pretreated Relapsed/Refractory (R/R) Mantle Cell Lymphoma (MCL), Including Those with a Poor Prognosis: Subgroup Results from a Phase I/II Study","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Mantle cell lymphoma; Medicine; Refractory (planetary science); Internal medicine; Lymphoma; Oncology; Gastroenterology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007646559,0.0003843969,0.0008213671,0.0002443246,0.0001608892,0.0004362086,0.0002137271,0.0002731922,0.001267925],"category_scores_gemma":[0.0005081655,0.0001804919,0.0007537309,0.0002598518,0.0002238398,0.0003265964,0.0001952289,0.0007606623,0.0003198049],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003080818,"about_ca_system_score_gemma":0.0002605481,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003857439,"about_ca_topic_score_gemma":0.001085001,"domain_scores_codex":[0.9998042,0.00006965899,0.00002327479,0.00004317255,0.00002380566,0.00003586192],"domain_scores_gemma":[0.9997209,0.00004817388,0.00008764756,0.00003883592,0.00001651671,0.00008795704],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3415887,0.01533425,0.09161787,0.0008236125,0.002730483,0.0004122476,0.0004564501,0.003073616,0.161673,0.00009862075,0.004406738,0.3777845],"study_design_scores_gemma":[0.1027394,0.4811874,0.3778579,0.00007074149,0.002689324,0.00225352,0.0002351513,0.00267732,0.02187904,0.0002215726,0.008129572,0.00005895793],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974554,0.00109542,0.0002055863,0.00007228446,0.00001069456,0.0002233349,0.0003108188,0.00004756521,0.0005788462],"genre_scores_gemma":[0.9979814,0.0005087881,0.0003210665,0.0001444254,0.00002488862,0.0001040707,0.0005983086,0.000009657182,0.0003074019],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001267925,"threshold_uncertainty_score":0.004241705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01768036479163166,"score_gpt":0.2715621329628678,"score_spread":0.2538817681712361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}