{"id":"W4405042905","doi":"10.1182/blood-2024-200300","title":"Pharmacodynamic Signatures and Correlatives of Response in Patients with Relapsed/Refractory Multiple Myeloma (RRMM) Treated with Talquetamab or Teclistamab Plus Daratumumab and Pomalidomide","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Princess Margaret Cancer Centre","funders":"Kite Pharma; Adaptive Biotechnologies; Regeneron Pharmaceuticals; Janssen Pharmaceuticals; Genentech; Celgene; Bristol-Myers Squibb; GlaxoSmithKline; Servier; Amgen","keywords":"Daratumumab; Pomalidomide; Medicine; Multiple myeloma; Lenalidomide; Internal medicine; Refractory (planetary science); Oncology; Pharmacodynamics; Biology; Pharmacokinetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003208215,0.0001858384,0.0004256317,0.0002967491,0.0001539831,0.0003821749,0.0001759,0.0002953373,0.0009395978],"category_scores_gemma":[0.0006859795,0.0001082275,0.000262824,0.0004004284,0.0001594127,0.0002474472,0.0001984722,0.0003662829,0.0002069808],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003661053,"about_ca_system_score_gemma":0.0001884482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004890434,"about_ca_topic_score_gemma":0.000815795,"domain_scores_codex":[0.9998007,0.00005099697,0.00002110912,0.00005455951,0.00003634187,0.00003623127],"domain_scores_gemma":[0.9996257,0.00007960867,0.0001500022,0.00001412459,0.00002284323,0.0001076861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02073583,0.0007841184,0.9379941,0.00007117075,0.0002994678,0.0004866715,0.000102716,0.0008109738,0.01108082,0.00006977869,0.0007256323,0.02683869],"study_design_scores_gemma":[0.0005190088,0.006686012,0.9883803,0.000008493641,0.0001442816,0.0008733182,0.00006701875,0.00130232,0.001083518,0.00006705218,0.0008592376,0.000009334366],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989246,0.0002641395,0.00005896133,0.00003911963,0.000003606515,0.00002032124,0.0002864029,0.000007094802,0.0003958329],"genre_scores_gemma":[0.9992405,0.00005630067,0.00007675044,0.00005260757,0.00001333851,0.0000184393,0.0003839789,0.000001469676,0.0001566199],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009395978,"threshold_uncertainty_score":0.003143311,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00999610232743083,"score_gpt":0.266600875427401,"score_spread":0.2566047730999702,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}