{"id":"W4405043173","doi":"10.1182/blood-2024-204166","title":"Comprehensive Characterization and Validation of the Tumor Microenvironment in Patients with Relapsed/Refractory Large B-Cell Lymphoma Identifies Subgroups with Greatest Benefit from CD19 CAR T-Cell Therapy","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC","funders":"Daiichi Sankyo Europe; National Cancer Institute; EMD Serono; Pharmacyclics; Genentech; Incyte; BeiGene; Regeneron Pharmaceuticals; Seagen; Janssen Pharmaceuticals; Gilead Sciences; MorphoSys; Cancer Prevention and Research Institute of Texas; Celgene; AstraZeneca; Bristol-Myers Squibb; TG Therapeutics; Amgen","keywords":"Tumor microenvironment; Lymphoma; Medicine; Refractory (planetary science); Diffuse large B-cell lymphoma; CD19; Oncology; Cancer research; Internal medicine; Tumor cells; Biology; Peripheral blood","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002398238,0.0001889403,0.0003346718,0.0006401644,0.0002152175,0.0004282213,0.000179566,0.0002172151,0.000679362],"category_scores_gemma":[0.0004663335,0.0001057204,0.0001857241,0.0003969693,0.0001576607,0.0001799395,0.0002926147,0.000193534,0.0002618905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002025473,"about_ca_system_score_gemma":0.0001355983,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006703301,"about_ca_topic_score_gemma":0.001221399,"domain_scores_codex":[0.9998178,0.00003060663,0.00001654589,0.0000637897,0.00003437716,0.00003698345],"domain_scores_gemma":[0.9998658,0.00003421386,0.00003525323,0.00001712619,0.0000196922,0.00002787739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001415604,0.00008235297,0.8235345,0.00005913418,0.00008036919,0.0006309517,0.0002589425,0.0006538494,0.1437826,0.0001111987,0.000426761,0.02896355],"study_design_scores_gemma":[0.00003026355,0.0002413671,0.9826173,0.00001151477,0.00008198321,0.001619046,0.0002709641,0.002174113,0.01151416,0.0001531074,0.001278716,0.000007501834],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987267,0.0002881987,0.0003583486,0.00001940101,0.000001313799,0.000009251136,0.0002897776,0.00001267803,0.0002942905],"genre_scores_gemma":[0.9987431,0.00007803382,0.0003418417,0.00002682707,0.000004407005,0.00001141643,0.0006938431,0.000006257545,0.00009434461],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000679362,"threshold_uncertainty_score":0.002272725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008359443956642763,"score_gpt":0.2083931354062878,"score_spread":0.2000336914496451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}