{"id":"W4405043414","doi":"10.1182/blood-2024-200871","title":"Phase 3 Randomized Study of Daratumumab (DARA) + Bortezomib, Lenalidomide and Dexamethasone (VRd) Versus Alone in Patients with Transplant-Ineligible Newly Diagnosed Multiple Myeloma or for Whom Transplant Is Not Planned As Initial Therapy: Analysis of Minimal Residual Disease in the Cepheus Trial","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Institute of Cancer Research; University of Alberta; University of Calgary","funders":"","keywords":"Lenalidomide; Daratumumab; Bortezomib; Medicine; Multiple myeloma; Dexamethasone; Internal medicine; Oncology; Transplantation; Thalidomide; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004562574,0.00149625,0.002680603,0.0003629999,0.0005017058,0.001421811,0.0008621156,0.001267123,0.004170072],"category_scores_gemma":[0.002562723,0.0005160398,0.002459414,0.000502449,0.001123416,0.001196942,0.0006975968,0.003415609,0.0005936462],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001216922,"about_ca_system_score_gemma":0.002014257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001264168,"about_ca_topic_score_gemma":0.003205166,"domain_scores_codex":[0.998489,0.001053886,0.00004277949,0.0001872363,0.00008027675,0.0001468214],"domain_scores_gemma":[0.9977957,0.0005969752,0.0005469366,0.0001985694,0.0001263234,0.0007354824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9831082,0.004419673,0.002072409,0.0001593853,0.001478513,0.00003778674,0.00004303335,0.0004824296,0.001071017,0.0001464042,0.001060767,0.005920264],"study_design_scores_gemma":[0.9166412,0.07268072,0.00653373,0.00002465069,0.001093599,0.00008014245,0.00004318523,0.001002929,0.0003251445,0.0003884222,0.001162538,0.00002377018],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916897,0.002019957,0.0004113395,0.0006483022,0.0002802466,0.00236443,0.001248505,0.00005748765,0.001280083],"genre_scores_gemma":[0.9876703,0.001016694,0.001907927,0.001408127,0.0003633115,0.0032473,0.002399771,0.00002697533,0.001959567],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004562574,"threshold_uncertainty_score":0.02412945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04351882518375011,"score_gpt":0.3480125436039243,"score_spread":0.3044937184201742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}