{"id":"W4405044256","doi":"10.1182/blood-2024-194610","title":"Efficacy and Safety of Pozelimab Plus Cemdisiran Vs Ravulizumab in Patients with Paroxysmal Nocturnal Hemoglobinuria Who Are Naïve to Complement Inhibition","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University Health Network","funders":"","keywords":"Paroxysmal nocturnal hemoglobinuria; Medicine; Internal medicine; Eculizumab; Clinical endpoint; Gastroenterology; Interim analysis; Neutropenia; Clinical trial; Surgery; Antibody; Immunology; Chemotherapy; Complement system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001348989,0.0002072085,0.0004031181,0.0001770397,0.00007850026,0.00002584436,0.0001087084,0.00007205825,0.0003334229],"category_scores_gemma":[0.00002532255,0.0001725211,0.00004801849,0.0002018164,0.00007624457,0.00006959296,0.0001339353,0.0001407988,0.00004486615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008196309,"about_ca_system_score_gemma":0.00006562837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006410175,"about_ca_topic_score_gemma":0.0001161222,"domain_scores_codex":[0.998609,0.0001446325,0.0004716132,0.0003712428,0.00009351917,0.0003099761],"domain_scores_gemma":[0.9994636,0.0000947045,0.0001077813,0.0002250217,0.00006425066,0.00004465639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02333208,0.005379697,0.9260734,0.00221534,0.0020653,0.0001561882,0.006532165,0.000210551,0.01590411,0.002039614,0.01089524,0.005196296],"study_design_scores_gemma":[0.02733679,0.001282349,0.9598426,0.001748312,0.0001926131,0.00002549035,0.0003142224,0.000005007885,0.005925865,0.0000317428,0.003003957,0.0002911064],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964678,0.001389753,0.00004174877,0.0002194771,0.0001834953,0.001033372,0.0004730954,0.00004670129,0.0001446134],"genre_scores_gemma":[0.9994571,0.000008581294,0.00005512833,0.00006076058,0.00002443006,0.00003658091,0.0002884337,0.00001934078,0.0000496903],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03376913,"threshold_uncertainty_score":0.7035208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00829089565356706,"score_gpt":0.2266210162547149,"score_spread":0.2183301206011479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}