{"id":"W4405044372","doi":"10.1182/blood-2024-201056","title":"Convergent Evolution Towards CD38 Biallelic Loss Is a Recurrent Mechanism of Resistance to Anti-CD38 Antibodies in Multiple Myeloma","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Multiple myeloma; CD38; Antibody; Mechanism (biology); Medicine; Immunology; Cancer research; Biology; Genetics; Stem cell; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001965982,0.0001776101,0.0002806077,0.0007305407,0.0002965847,0.0003663749,0.000220943,0.0002706169,0.001137359],"category_scores_gemma":[0.0003580995,0.0001112661,0.0001589195,0.0005306721,0.0002633593,0.000127676,0.0003284596,0.0002164466,0.0002384228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002203469,"about_ca_system_score_gemma":0.0001045154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009409321,"about_ca_topic_score_gemma":0.001344493,"domain_scores_codex":[0.9997023,0.00003951122,0.00002510952,0.00009283672,0.00008272123,0.00005754515],"domain_scores_gemma":[0.9997633,0.00005204679,0.00008772019,0.00003724338,0.00002915137,0.00003046687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004375245,0.00005814952,0.4571879,0.00005975471,0.00006445521,0.003065612,0.0004806809,0.0002784833,0.5203441,0.0002095235,0.0002020574,0.01761177],"study_design_scores_gemma":[0.00001310781,0.0002240645,0.9421633,0.000007903536,0.00006356273,0.01552879,0.0002546758,0.0008368257,0.0393597,0.0001092504,0.001428893,0.000009834929],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991983,0.0001411076,0.0002711092,0.00001465286,7.045223e-7,0.000006264583,0.00006606211,0.000009692289,0.0002920234],"genre_scores_gemma":[0.99944,0.00005604099,0.0002396322,0.000018874,0.000002799493,0.000003898747,0.0001083707,0.000004203535,0.000126116],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001137359,"threshold_uncertainty_score":0.003804803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03242307861881754,"score_gpt":0.3096346920862939,"score_spread":0.2772116134674764,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}