{"id":"W4405044374","doi":"10.1182/blood-2024-198147","title":"BRUIN CLL-321: Randomized Phase III Trial of Pirtobrutinib Versus Idelalisib Plus Rituximab (IdelaR) or Bendamustine Plus Rituximab (BR) in BTK Inhibitor Pretreated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Bendamustine; Idelalisib; Rituximab; Chronic lymphocytic leukemia; Ibrutinib; Medicine; Ofatumumab; Obinutuzumab; Bruton's tyrosine kinase; Venetoclax; Internal medicine; Oncology; Leukemia; Lymphoma; Tyrosine kinase; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.003740025,0.001693342,0.005822615,0.00206881,0.0002508262,0.0003139599,0.001174048,0.001303517,0.0009267868],"category_scores_gemma":[0.004806027,0.001397276,0.001575983,0.003713838,0.001403381,0.0005457549,0.0007547823,0.001009514,0.000491435],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.2050655,"about_ca_system_score_gemma":0.2208137,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01409416,"about_ca_topic_score_gemma":0.001291261,"domain_scores_codex":[0.9865317,0.0009664505,0.004525166,0.002563597,0.002676355,0.002736671],"domain_scores_gemma":[0.9903462,0.004805365,0.000781232,0.002363172,0.0006089505,0.001095063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9644564,0.004122943,0.000001592448,0.003899149,0.002976917,0.01060343,0.001387878,0.0008805374,0.003005653,0.0003396665,0.001373031,0.006952848],"study_design_scores_gemma":[0.7417808,0.004334666,0.000001796897,0.003135343,0.003571127,0.001833175,0.0002583838,0.2217086,0.02128066,0.00006437065,0.001051513,0.0009796481],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9662197,0.01742824,0.0002366099,0.0001547948,0.002563201,0.009257351,0.0002784393,0.0009029506,0.002958697],"genre_scores_gemma":[0.9884765,0.002408887,0.0007077451,0.0001284699,0.002413327,0.001319069,0.0006243772,0.0004527655,0.003468854],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2226756,"threshold_uncertainty_score":0.999993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03746451672600935,"score_gpt":0.3310610606163402,"score_spread":0.2935965438903309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}