{"id":"W4405044374","doi":"10.1182/blood-2024-198147","title":"BRUIN CLL-321: Randomized Phase III Trial of Pirtobrutinib Versus Idelalisib Plus Rituximab (IdelaR) or Bendamustine Plus Rituximab (BR) in BTK Inhibitor Pretreated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Bendamustine; Idelalisib; Rituximab; Chronic lymphocytic leukemia; Ibrutinib; Medicine; Ofatumumab; Obinutuzumab; Bruton's tyrosine kinase; Venetoclax; Internal medicine; Oncology; Leukemia; Lymphoma; Tyrosine kinase; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002796929,0.002529837,0.002119409,0.0004860084,0.0005037791,0.001324508,0.001429053,0.002077539,0.009090461],"category_scores_gemma":[0.00183867,0.0009004514,0.001469385,0.0003969061,0.001430805,0.00125758,0.0006564176,0.003224937,0.001915131],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001401137,"about_ca_system_score_gemma":0.001730114,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001166012,"about_ca_topic_score_gemma":0.002866779,"domain_scores_codex":[0.9992643,0.0004439012,0.00003453917,0.0001072498,0.00004371031,0.0001062439],"domain_scores_gemma":[0.9990025,0.0002297297,0.0002667428,0.00006989714,0.00005343002,0.0003776943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9788015,0.006159715,0.0005694957,0.000397373,0.0003910362,0.00003263638,0.00004727224,0.000418275,0.002354873,0.0001295223,0.001222939,0.009475335],"study_design_scores_gemma":[0.9562918,0.04120171,0.0008801264,0.00002745395,0.0001981416,0.00003192109,0.00001663881,0.0003360206,0.0001944939,0.0001666397,0.0006458081,0.000009344853],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9753302,0.004202108,0.0007619788,0.001415665,0.0007003472,0.00898874,0.002780552,0.0002946652,0.00552567],"genre_scores_gemma":[0.977038,0.00240147,0.001698742,0.001924898,0.0006267248,0.008187892,0.002658597,0.00005380064,0.005409847],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009090461,"threshold_uncertainty_score":0.03041059,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03746451672600935,"score_gpt":0.3310610606163402,"score_spread":0.2935965438903309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}