{"id":"W4405044387","doi":"10.1016/s1473-3099(24)00667-4","title":"Breadth of immune response, immunogenicity, reactogenicity, and safety for a pentavalent meningococcal ABCWY vaccine in healthy adolescents and young adults: results from a phase 3, randomised, controlled observer-blinded trial","year":2024,"lang":"en","type":"article","venue":"The Lancet Infectious Diseases","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Dalhousie University","funders":"GlaxoSmithKline Biologicals","keywords":"Reactogenicity; Meningococcal vaccine; Medicine; Immunogenicity; Vaccination; Meningococcal disease; Randomized controlled trial; Pediatrics; Neisseria meningitidis; Immune system; Internal medicine; Immunology; Immunization; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001236858,0.0003076532,0.001166827,0.0001805897,0.0002531804,0.00007621481,0.0001706762,0.0001908668,0.00004816239],"category_scores_gemma":[0.0009759194,0.000213101,0.0002921086,0.0002144312,0.0001129048,0.0001433516,0.0001454661,0.0002941282,0.00000447621],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007574276,"about_ca_system_score_gemma":0.0001289831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002958118,"about_ca_topic_score_gemma":0.0006659857,"domain_scores_codex":[0.9971253,0.0008839762,0.001078571,0.0004749429,0.00004184724,0.0003953922],"domain_scores_gemma":[0.9972997,0.001829631,0.0003227165,0.0003978642,0.00009939159,0.0000507346],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.931053,0.0009929024,0.004407105,0.0001336566,0.0006958758,0.000002652569,0.0005712284,0.000002204602,0.05897212,0.00004990776,0.0002091755,0.002910112],"study_design_scores_gemma":[0.9111892,0.002667317,0.08130538,0.0005649314,0.0005969822,0.00005475433,0.0001313018,0.0001032128,0.001653424,0.0002708542,0.00120344,0.0002592152],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9794049,0.01178114,0.0000389317,0.0005458828,0.001379605,0.003888177,0.002809187,0.0001362044,0.00001596031],"genre_scores_gemma":[0.9958684,0.002924067,0.00000490601,0.0000642091,0.0002795811,0.0004264807,0.0003736283,0.00002861345,0.00003005399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07689828,"threshold_uncertainty_score":0.8690009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02385561310237465,"score_gpt":0.3071313646560432,"score_spread":0.2832757515536686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}