{"id":"W4405044387","doi":"10.1016/s1473-3099(24)00667-4","title":"Breadth of immune response, immunogenicity, reactogenicity, and safety for a pentavalent meningococcal ABCWY vaccine in healthy adolescents and young adults: results from a phase 3, randomised, controlled observer-blinded trial","year":2024,"lang":"en","type":"article","venue":"The Lancet Infectious Diseases","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Dalhousie University","funders":"GlaxoSmithKline Biologicals","keywords":"Reactogenicity; Meningococcal vaccine; Medicine; Immunogenicity; Vaccination; Meningococcal disease; Randomized controlled trial; Pediatrics; Neisseria meningitidis; Immune system; Internal medicine; Immunology; Immunization; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003748587,0.001470213,0.003451812,0.0003334215,0.0005567768,0.001159836,0.0008776003,0.002385282,0.00268282],"category_scores_gemma":[0.004062707,0.0007307158,0.002154919,0.0004173516,0.001672051,0.001181755,0.0004858792,0.002880035,0.0004770717],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008405765,"about_ca_system_score_gemma":0.001017527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001242987,"about_ca_topic_score_gemma":0.001183532,"domain_scores_codex":[0.9978358,0.001148718,0.0002039971,0.0003862954,0.0002236569,0.0002015222],"domain_scores_gemma":[0.9968336,0.0012207,0.0008356184,0.0002768021,0.0002511065,0.0005821208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9836397,0.003788944,0.001342824,0.0003903445,0.0009978864,0.00001818102,0.00008585226,0.0001423245,0.002037835,0.00003300613,0.0001528156,0.007370383],"study_design_scores_gemma":[0.8027424,0.1866382,0.008052833,0.00005847665,0.0009418186,0.00003882304,0.00004456222,0.0003051951,0.0007005002,0.0001380478,0.0003113015,0.00002788372],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950261,0.001756508,0.0003643249,0.0001117962,0.0001639135,0.001813523,0.0003116098,0.00002861952,0.0004236729],"genre_scores_gemma":[0.9952099,0.0007796921,0.0007422398,0.0002679257,0.0001663252,0.001997323,0.0003099869,0.00001204045,0.0005146527],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003748587,"threshold_uncertainty_score":0.01982462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02385561310237465,"score_gpt":0.3071313646560432,"score_spread":0.2832757515536686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}