{"id":"W4405044459","doi":"10.1182/blood-2024-199781","title":"Prognostication and Treatment-Related Outcomes in Secondary Central Nervous System Involvement of Large B-Cell Lymphoma (SCNSL): Evidence from a Large International Cohort","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"CNS Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Internal medicine; Interquartile range; Oncology; BCL6; Proportional hazards model; Median follow-up; Progression-free survival; ThioTEPA; Concomitant; Chemotherapy regimen; Cohort; Rituximab; Chemotherapy; Surgery; Lymphoma; Germinal center; Immunology; Cyclophosphamide; B cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001161192,0.0001881738,0.0002458109,0.0006979237,0.0001909388,0.0005767093,0.0002635108,0.000166783,0.001416278],"category_scores_gemma":[0.002441693,0.00008257863,0.0002999882,0.00112323,0.0004274827,0.0002710755,0.0003624936,0.0002333008,0.0001678186],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002742525,"about_ca_system_score_gemma":0.0003054995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00252461,"about_ca_topic_score_gemma":0.003371525,"domain_scores_codex":[0.9996237,0.0001449843,0.00003935761,0.00008555624,0.00006286924,0.00004350695],"domain_scores_gemma":[0.9978102,0.0004569179,0.001175737,0.0001613267,0.0001898432,0.0002060493],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003275264,0.00001268857,0.9956753,0.00002221435,0.00009605156,0.00003459176,0.00002744305,0.00005254145,0.0001087498,0.00001013471,0.00009694173,0.003535765],"study_design_scores_gemma":[0.00003247602,0.0002022654,0.9984307,0.000028306,0.0001515437,0.0003864393,0.00008275637,0.0001242919,0.00009818345,0.00003161899,0.0004288149,0.000002612257],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977039,0.001148548,0.00007012857,0.0000470741,0.000003593242,0.000007787895,0.0004062971,0.000003200605,0.0006095209],"genre_scores_gemma":[0.9988561,0.0003891938,0.00004665841,0.0000250258,0.00001124248,0.000006116289,0.0006198522,0.000001810826,0.00004417554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00252461,"threshold_uncertainty_score":0.006141007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01060091049514734,"score_gpt":0.2566997809161092,"score_spread":0.2460988704209618,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}