{"id":"W4405044472","doi":"10.1182/blood-2024-200867","title":"ENERGIZE-T: A Global, Phase 3, Double-Blind, Randomized, Placebo-Controlled Study of Mitapivat in Adults with Transfusion-Dependent Alpha- or Beta-Thalassemia","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Medicine; Placebo; Thalassemia; Double blind; Beta thalassemia; Blood transfusion; Alpha (finance); BETA (programming language); Internal medicine; Surgery; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001262827,0.001551797,0.002308436,0.0005123594,0.0004492998,0.0009727028,0.0008275384,0.001953934,0.009237493],"category_scores_gemma":[0.001111779,0.0006199672,0.001810714,0.0004103477,0.0009826898,0.001043418,0.0004638685,0.002769413,0.001085526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004849648,"about_ca_system_score_gemma":0.001050052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005660559,"about_ca_topic_score_gemma":0.001697135,"domain_scores_codex":[0.9996031,0.0001904208,0.00002771792,0.00009362197,0.00003106339,0.00005401064],"domain_scores_gemma":[0.9994672,0.0001260254,0.0001666806,0.00002920896,0.00004955923,0.0001613436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9503778,0.009331875,0.0009017284,0.00315758,0.002773768,0.00006685791,0.00008388765,0.0003140662,0.005164281,0.000215427,0.002270544,0.02534218],"study_design_scores_gemma":[0.9683998,0.02836136,0.001263769,0.00007917207,0.0007191149,0.00003075442,0.00001745905,0.000134076,0.000260702,0.00009150777,0.0006322137,0.00001014156],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9401184,0.02722015,0.002248601,0.002388296,0.001202707,0.01576932,0.003453051,0.0007150683,0.006884451],"genre_scores_gemma":[0.9560742,0.01065315,0.003932826,0.004549152,0.0007018907,0.01665367,0.002054239,0.00007105847,0.00530977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009237493,"threshold_uncertainty_score":0.0309025,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01224744999699763,"score_gpt":0.285217193466863,"score_spread":0.2729697434698654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}