{"id":"W4405044516","doi":"10.1182/blood-2024-203719","title":"A Phase 1b Study of DISC-0974, an Anti-Hemojuvelin Antibody, in Patients with Myelofibrosis and Anemia","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Servier; Ionis Pharmaceuticals; Astellas Pharma; Karyopharm Therapeutics; Galecto; Sierra Oncology; CTI Biopharma; Incyte; Agios Pharmaceuticals; Jazz Pharmaceuticals; Gilead Sciences; MorphoSys; Celgene","keywords":"Myelofibrosis; Medicine; Anemia; Antibody; Internal medicine; Immunology; Bone marrow","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001009098,0.0009598745,0.00160307,0.0003301666,0.00032726,0.0006254448,0.0006095236,0.0009284547,0.004893658],"category_scores_gemma":[0.0006683793,0.0004392256,0.0006779465,0.0002403959,0.0005183225,0.0005030771,0.0002436441,0.001665734,0.0007812835],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006919259,"about_ca_system_score_gemma":0.00126055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006853685,"about_ca_topic_score_gemma":0.002420038,"domain_scores_codex":[0.9997415,0.0001096963,0.00001434262,0.00005482751,0.00002781285,0.00005187807],"domain_scores_gemma":[0.9996148,0.00005604882,0.00006790651,0.00002374374,0.00003995838,0.000197529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6702094,0.0891453,0.01149453,0.002379004,0.001504069,0.0005715809,0.000377502,0.002193862,0.06436854,0.0005656113,0.01066435,0.1465262],"study_design_scores_gemma":[0.5726708,0.3998792,0.01387409,0.00006718647,0.0005233288,0.0005536468,0.00007331341,0.001126661,0.003865818,0.0002900843,0.007041904,0.00003406212],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829792,0.004209714,0.0009022134,0.0006345797,0.0001836002,0.005729979,0.002542976,0.0001745568,0.002643108],"genre_scores_gemma":[0.9824568,0.002056426,0.002968535,0.001457273,0.0001705238,0.00399756,0.00277642,0.00002855139,0.004087852],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004893658,"threshold_uncertainty_score":0.01637095,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009992879252824242,"score_gpt":0.2989883328668275,"score_spread":0.2889954536140033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}