{"id":"W4405044519","doi":"10.1182/blood-2024-193678","title":"Apex Part 1: Updated Assessment of Bezuclastinib (CGT9486), a Selective KIT D816V Tyrosine Kinase Inhibitor, in Patients with Advanced Systemic Mastocytosis (AdvSM)","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"","keywords":"Systemic mastocytosis; Apex (geometry); Tyrosine-kinase inhibitor; Medicine; Tyrosine kinase; Internal medicine; Cancer research; Bone marrow; Cancer; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003473656,0.0009279895,0.00238302,0.0004690639,0.0003065627,0.001479136,0.001226093,0.001397275,0.004649788],"category_scores_gemma":[0.003004953,0.0004979225,0.00196289,0.0005742526,0.0004362887,0.001255248,0.0005786006,0.003104057,0.001025137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008994148,"about_ca_system_score_gemma":0.001129294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004221612,"about_ca_topic_score_gemma":0.001755889,"domain_scores_codex":[0.9990616,0.0003974475,0.00009383059,0.0001471802,0.0001833314,0.0001165513],"domain_scores_gemma":[0.9980627,0.0004486525,0.000530047,0.0001320406,0.0003838885,0.0004425985],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5068,0.005934462,0.02416463,0.004721807,0.005936245,0.0005146157,0.0004794889,0.006260194,0.02811499,0.001400269,0.04338954,0.3722839],"study_design_scores_gemma":[0.64135,0.1991693,0.07474369,0.0008719442,0.007791859,0.001908655,0.0001874144,0.004184389,0.005641955,0.002296573,0.06165971,0.0001944834],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8822433,0.0571996,0.003090149,0.00632243,0.0008779805,0.005814617,0.02316002,0.000539673,0.0207522],"genre_scores_gemma":[0.9267637,0.02017479,0.005397624,0.00687871,0.0008548879,0.004592505,0.03043408,0.0001431303,0.004760483],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004649788,"threshold_uncertainty_score":0.01837069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004700900751679946,"score_gpt":0.2099301078373033,"score_spread":0.2052292070856233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}