{"id":"W4405044519","doi":"10.1182/blood-2024-193678","title":"Apex Part 1: Updated Assessment of Bezuclastinib (CGT9486), a Selective KIT D816V Tyrosine Kinase Inhibitor, in Patients with Advanced Systemic Mastocytosis (AdvSM)","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"","keywords":"Systemic mastocytosis; Apex (geometry); Tyrosine-kinase inhibitor; Medicine; Tyrosine kinase; Internal medicine; Cancer research; Bone marrow; Cancer; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001283259,0.0002575895,0.0004551533,0.0002286417,0.00006388382,0.00001642066,0.0001360114,0.0001771831,0.0003515282],"category_scores_gemma":[0.0000149353,0.0002101642,0.00006498254,0.0004795214,0.0001150552,0.0001006869,0.00006947864,0.0003365749,0.00006132715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008090816,"about_ca_system_score_gemma":0.0001659154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005825869,"about_ca_topic_score_gemma":0.00007472101,"domain_scores_codex":[0.9984997,0.0001225357,0.000465093,0.0004659447,0.00008201695,0.0003646996],"domain_scores_gemma":[0.9993652,0.0000675934,0.0001440795,0.0002537505,0.0001380318,0.00003138907],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001549371,0.006617883,0.1923501,0.001194395,0.00135922,0.0001019981,0.001018202,0.0001432721,0.7860411,0.001226292,0.003588246,0.004809855],"study_design_scores_gemma":[0.05821157,0.01109688,0.3113401,0.006058119,0.00167518,0.0001617919,0.00063603,0.0001266892,0.5414588,0.00004695932,0.06700253,0.002185338],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953771,0.001887235,0.00004339544,0.00003146852,0.0004432535,0.0006360899,0.0002576138,0.00007983404,0.00124404],"genre_scores_gemma":[0.9982145,0.0000377696,0.0001872284,0.00002058633,0.0000268137,0.00008648629,0.0005806406,0.00003699983,0.0008089179],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2445824,"threshold_uncertainty_score":0.8570247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004700900751679946,"score_gpt":0.2099301078373033,"score_spread":0.2052292070856233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}