{"id":"W4405044791","doi":"10.1182/blood-2024-204533","title":"Clinical Outcomes over 3 Years of Once-Weekly Efanesoctocog Alfa Treatment in Adults and Adolescents with Severe Hemophilia A: Second Interim Analysis from the Phase 3 XTEND-ed Long-Term Extension Study","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Medicine; Interim analysis; Interim; Pediatrics; Term (time); Clinical trial; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005887609,0.000953128,0.001747828,0.0004683441,0.0004727746,0.001179328,0.0005318145,0.0009613865,0.002138144],"category_scores_gemma":[0.002885589,0.0003950546,0.002979063,0.0004535133,0.0003974563,0.0008874472,0.0006018241,0.00198198,0.0004714936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005500955,"about_ca_system_score_gemma":0.0009579955,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007438716,"about_ca_topic_score_gemma":0.0009286657,"domain_scores_codex":[0.9982879,0.0007420643,0.0001449382,0.0002539174,0.0002706161,0.000300603],"domain_scores_gemma":[0.9968541,0.000553264,0.001320169,0.0003152546,0.0003587317,0.000598522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5374649,0.01674656,0.3453548,0.0007882938,0.008782298,0.0004575597,0.0003622462,0.004103049,0.007005572,0.0002964396,0.007349574,0.07128869],"study_design_scores_gemma":[0.06754397,0.2638257,0.6488734,0.0001464079,0.006882549,0.0006461503,0.0001992215,0.0020895,0.003615383,0.0003310013,0.00574208,0.0001047044],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881688,0.001609329,0.0008065217,0.0001763241,0.00004629952,0.0009985928,0.006524812,0.00005497464,0.001614454],"genre_scores_gemma":[0.9832804,0.0004391343,0.0009065692,0.0003235646,0.00008266282,0.001785802,0.01187902,0.00001494318,0.001288017],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005887609,"threshold_uncertainty_score":0.03113705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0356453508364374,"score_gpt":0.3805165965895844,"score_spread":0.344871245753147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}