{"id":"W4405044949","doi":"10.1182/blood-2024-201288","title":"Genomic Determinants of Resistance to Anti-BCMA Chimeric Antigen Receptor T-Cell (CART) Therapies in Patients with Relapsed/Refractory Multiple Myeloma","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Chimeric antigen receptor; Medicine; Cart; Multiple myeloma; Refractory (planetary science); Oncology; Lenalidomide; Internal medicine; Cancer research; Immunology; Immunotherapy; Biology; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001702182,0.0001303545,0.0002294131,0.0003309453,0.0001650511,0.0003521578,0.0001446035,0.0003305007,0.001002647],"category_scores_gemma":[0.0007652857,0.0001194502,0.0001264986,0.0004174473,0.0001663237,0.0002097791,0.0001955074,0.0002707354,0.0001712548],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001817963,"about_ca_system_score_gemma":0.00007842966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009038972,"about_ca_topic_score_gemma":0.001045279,"domain_scores_codex":[0.9998597,0.00003154887,0.00001330084,0.00004473516,0.00002515724,0.00002550861],"domain_scores_gemma":[0.9997966,0.00006227949,0.0000886057,0.00001659274,0.00001322646,0.00002275424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001525363,0.00009440576,0.9627704,0.00002619806,0.0001063976,0.0007073879,0.0002687788,0.0005034976,0.01855811,0.0000551396,0.0002991432,0.01508525],"study_design_scores_gemma":[0.00002835995,0.0002820872,0.9953453,0.000005596075,0.00005252473,0.00153667,0.0001520539,0.0008047742,0.001260824,0.00006442778,0.000462741,0.000004606771],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996287,0.0001127364,0.00003399868,0.00002170237,8.31177e-7,0.00000208819,0.000103463,0.000002263143,0.00009415471],"genre_scores_gemma":[0.999621,0.0000502077,0.00005159617,0.00001909679,0.000002400224,0.000002731189,0.0001732821,0.000001440327,0.00007822638],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001002647,"threshold_uncertainty_score":0.003354192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.010942681774476,"score_gpt":0.2501756502306125,"score_spread":0.2392329684561365,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}