{"id":"W4405044954","doi":"10.1182/blood-2024-205608","title":"Phase 3 Study of Teclistamab (Tec) in Combination with Lenalidomide (Len) and Tec Alone Versus Len Alone in Newly Diagnosed Multiple Myeloma (NDMM) As Maintenance Therapy Following Autologous Stem Cell Transplantation (ASCT): Safety Run-in (SRI) Results from the Majestec-4/EMN30 Trial","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; TEC; Lenalidomide; Internal medicine; Oncology; Multiple myeloma; Cohort; Autologous stem-cell transplantation; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002020202,0.001259469,0.001986026,0.0003014044,0.0003871896,0.001205167,0.0008411774,0.001086318,0.003752944],"category_scores_gemma":[0.0008147341,0.0004992582,0.001864139,0.0003733967,0.0008557951,0.0008212697,0.0004261429,0.003876194,0.000979759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001069091,"about_ca_system_score_gemma":0.001898403,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008300352,"about_ca_topic_score_gemma":0.002071228,"domain_scores_codex":[0.9995996,0.0001758204,0.00002288205,0.00007699183,0.00004497738,0.00007976314],"domain_scores_gemma":[0.9993837,0.00008452782,0.0001321017,0.00005437638,0.00003966873,0.0003056414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8979047,0.0362331,0.004201302,0.0005234452,0.001647266,0.0001578178,0.0001540887,0.001493512,0.01872182,0.0001707831,0.002405518,0.03638677],"study_design_scores_gemma":[0.6844928,0.2982562,0.009475213,0.00004641922,0.0009950798,0.0002823189,0.00004440489,0.0009435595,0.002799635,0.0002911054,0.002343322,0.00003000657],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911316,0.002008181,0.0004509639,0.0004959104,0.0001495228,0.002346038,0.001462566,0.0001014605,0.001853709],"genre_scores_gemma":[0.9879377,0.001400333,0.001541586,0.0008562767,0.0001675737,0.002792151,0.003005252,0.00003360096,0.002265607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003752944,"threshold_uncertainty_score":0.01255488,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02588443696714383,"score_gpt":0.2991773898175876,"score_spread":0.2732929528504438,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}