{"id":"W4405045207","doi":"10.1182/blood-2024-207207","title":"Pharmacokinetics/Pharmacodynamics, Safety, and Efficacy of Crizanlizumab in Patients with Sickle Cell Disease Aged 6 to <12 Years: 2-Year Data from the Phase 2 Solace-Kids Study","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto","funders":"","keywords":"Medicine; Dosing; Pharmacokinetics; Pharmacodynamics; Internal medicine; Clinical trial; Adverse effect; Pediatrics; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001225057,0.0003273376,0.0008641227,0.0002114301,0.0003039324,0.0005593179,0.0002194253,0.0003915717,0.0007537359],"category_scores_gemma":[0.001091295,0.0002058943,0.00080217,0.0002993622,0.0002214555,0.000325755,0.0002340149,0.0008659022,0.0002365928],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003965622,"about_ca_system_score_gemma":0.0004485317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001036959,"about_ca_topic_score_gemma":0.001393458,"domain_scores_codex":[0.9995918,0.0001083494,0.00004844471,0.00008907109,0.00009369156,0.00006870112],"domain_scores_gemma":[0.998958,0.0001682224,0.0004650075,0.00006815107,0.00009025959,0.0002503273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.05057415,0.001858366,0.8809007,0.0002719945,0.001111189,0.0009109285,0.0003735918,0.001491787,0.01793476,0.00007063588,0.001771744,0.04273007],"study_design_scores_gemma":[0.004117864,0.03098491,0.9560408,0.00003722831,0.000553207,0.001976596,0.00009988109,0.0008771628,0.002403678,0.00006028074,0.002810825,0.00003767304],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974069,0.001468437,0.0001456286,0.00005018998,0.000005761214,0.00003963439,0.0005572082,0.000007481064,0.0003187978],"genre_scores_gemma":[0.9975006,0.0004795158,0.0002547634,0.0001510333,0.00002367058,0.00004702897,0.001314465,0.000003072034,0.00022576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001225057,"threshold_uncertainty_score":0.006478786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01409319437082018,"score_gpt":0.2866161024950908,"score_spread":0.2725229081242706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}