{"id":"W4405045328","doi":"10.1182/blood-2024-207793","title":"Genetic or Epigenetic CR1 Deficiency Defines Catastrophic Antiphospholipid Syndrome (CAPS) and Response to Complement Inhibition","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Joseph's Hospital","funders":"","keywords":"Catastrophic antiphospholipid syndrome; Antiphospholipid syndrome; Immunology; Medicine; Epigenetics; Genetics; Biology; Antibody; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000331683,0.000252908,0.0002660078,0.0002477941,0.0003128869,0.00007002513,0.0001724765,0.0001258288,0.0004166579],"category_scores_gemma":[0.00008272287,0.0002115349,0.00007158934,0.0004164112,0.0001901747,0.00006566158,0.000151701,0.0001979672,0.0008218715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000230338,"about_ca_system_score_gemma":0.0001329004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001227148,"about_ca_topic_score_gemma":0.000009715681,"domain_scores_codex":[0.9983327,0.0001846211,0.0003946888,0.0005059983,0.00006307268,0.0005188724],"domain_scores_gemma":[0.9994311,0.0001390341,0.00004430045,0.0003297575,0.0000369174,0.00001894353],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006344695,0.0006900563,0.001094495,0.0001766511,0.0001375576,0.0002973182,0.001788292,0.00005593002,0.9844959,0.00038453,0.0003929906,0.009851861],"study_design_scores_gemma":[0.008850585,0.006187277,0.6755109,0.001174342,0.0008371614,0.009299816,0.002372936,0.00004219979,0.195042,0.00057682,0.09810732,0.001998668],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9193309,0.07881049,0.0002669996,0.0003767131,0.0005201804,0.000384554,0.0001067324,0.0001342737,0.0000691812],"genre_scores_gemma":[0.9986016,0.0003666116,0.0001798049,0.0001623981,0.000004467745,0.00006603408,0.00006501119,0.00002986413,0.000524278],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7894539,"threshold_uncertainty_score":0.9999561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01045554069770348,"score_gpt":0.2322427658140544,"score_spread":0.2217872251163509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}