{"id":"W4405045328","doi":"10.1182/blood-2024-207793","title":"Genetic or Epigenetic CR1 Deficiency Defines Catastrophic Antiphospholipid Syndrome (CAPS) and Response to Complement Inhibition","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Joseph's Hospital","funders":"","keywords":"Catastrophic antiphospholipid syndrome; Antiphospholipid syndrome; Immunology; Medicine; Epigenetics; Genetics; Biology; Antibody; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000145506,0.0004792732,0.000247985,0.0007429789,0.0001577424,0.0002737948,0.0002293367,0.0004453156,0.002423129],"category_scores_gemma":[0.0004315254,0.0001385352,0.0001653564,0.0003273664,0.0004169072,0.0001465841,0.0002943742,0.0002743953,0.0003301231],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001883927,"about_ca_system_score_gemma":0.0001335468,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003284261,"about_ca_topic_score_gemma":0.0003210482,"domain_scores_codex":[0.9998108,0.00002190379,0.00002083875,0.00006863711,0.00004849226,0.00002935026],"domain_scores_gemma":[0.9997923,0.00003141236,0.0001107805,0.00001145607,0.00001854654,0.00003552772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001145565,0.0001429149,0.06378646,0.000150516,0.00007840372,0.01404435,0.0001509223,0.0002649787,0.9072729,0.0009175538,0.0006409182,0.01140456],"study_design_scores_gemma":[0.0002077166,0.001463431,0.5932086,0.00009482311,0.0002807995,0.1769625,0.0002868745,0.002909992,0.2124618,0.001068952,0.01099153,0.00006298841],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957652,0.0004704643,0.00132756,0.00007767578,0.00001723223,0.00003577995,0.000296108,0.00005564957,0.001954306],"genre_scores_gemma":[0.9980087,0.0002563852,0.000982691,0.00006584779,0.00001666412,0.00001686718,0.0002974847,0.00001239435,0.0003431725],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002423129,"threshold_uncertainty_score":0.008106232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01045554069770348,"score_gpt":0.2322427658140544,"score_spread":0.2217872251163509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}