{"id":"W4405045412","doi":"10.1182/blood-2024-198669","title":"Phase I Study of Belantamab Mafodotin in Combination with Standard of Care in Transplant-Ineligible Newly Diagnosed Multiple Myeloma: Dreamm-9 Updated Interim Analysis","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Tolerability; Medicine; Lenalidomide; Multiple myeloma; Interim analysis; Adverse effect; Clinical endpoint; Internal medicine; Bortezomib; Data monitoring committee; Oncology; Surgery; Urology; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004882851,0.001046262,0.002221667,0.000410273,0.0004072853,0.001551355,0.001100658,0.0008786434,0.004941921],"category_scores_gemma":[0.002644179,0.0004685631,0.002744406,0.0004562344,0.0005905663,0.0009623822,0.0005863114,0.003367377,0.001203817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001070866,"about_ca_system_score_gemma":0.002063462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000593406,"about_ca_topic_score_gemma":0.001363718,"domain_scores_codex":[0.9988304,0.0005775795,0.00006664503,0.0001659468,0.0001520205,0.0002073237],"domain_scores_gemma":[0.9986892,0.0002448549,0.0003513555,0.0002484267,0.0001212422,0.0003450105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8191835,0.01922191,0.01056637,0.001118269,0.004670674,0.0001671414,0.0001762423,0.007339048,0.01399097,0.0009075527,0.01378741,0.108871],"study_design_scores_gemma":[0.5838756,0.3674738,0.02035485,0.0001516308,0.003364934,0.0004523207,0.0000858229,0.003383159,0.004951114,0.001804925,0.01403643,0.00006555479],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.949128,0.006331787,0.005334124,0.001640899,0.0006777133,0.008063949,0.01644558,0.0005626827,0.01181514],"genre_scores_gemma":[0.95341,0.002325564,0.009090233,0.002128693,0.0002223861,0.009209357,0.01802923,0.0001064661,0.005478231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004941921,"threshold_uncertainty_score":0.02582335,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01507807223776512,"score_gpt":0.315646823370327,"score_spread":0.3005687511325619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}