{"id":"W4405045589","doi":"10.1182/blood-2024-198728","title":"BGB-11417-203, an Ongoing, Phase 2 Study of Sonrotoclax (BGB-11417), a Next-Generation BCL2 Inhibitor, in Patients With Waldenström Macroglobulinemia","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Waldenstrom macroglobulinemia; Macroglobulinemia; Ibrutinib; Medicine; Immunology; Leukemia; Multiple myeloma; Lymphoma; Chronic lymphocytic leukemia","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002551137,0.001697577,0.001792519,0.0005913481,0.0007855626,0.001102437,0.001499179,0.001886804,0.006220043],"category_scores_gemma":[0.0008449213,0.0006094827,0.001115829,0.0008099457,0.0007506165,0.0009370713,0.0005199569,0.003730169,0.002769555],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001633709,"about_ca_system_score_gemma":0.003846318,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002503249,"about_ca_topic_score_gemma":0.00687847,"domain_scores_codex":[0.9993379,0.0002870758,0.00003397349,0.00007680997,0.0001011434,0.0001631672],"domain_scores_gemma":[0.9991758,0.00007727395,0.0001533701,0.00004710993,0.00008554173,0.0004608023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3447458,0.07957904,0.04250608,0.002957278,0.00282275,0.001271017,0.0005024594,0.00377548,0.1276463,0.0009859062,0.06365379,0.3295541],"study_design_scores_gemma":[0.5869911,0.3115405,0.04541487,0.0002190488,0.001142461,0.001450913,0.0001170637,0.00145378,0.01089976,0.0005602338,0.04013625,0.00007405041],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9330592,0.01701671,0.001619741,0.004390717,0.000510584,0.01609425,0.01434767,0.0007826823,0.01217855],"genre_scores_gemma":[0.8957878,0.0107293,0.009344534,0.009250238,0.0005747123,0.01938156,0.04130858,0.0001972419,0.013426],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006220043,"threshold_uncertainty_score":0.0208081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03512004748815195,"score_gpt":0.324881224338984,"score_spread":0.289761176850832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}