{"id":"W4405045589","doi":"10.1182/blood-2024-198728","title":"BGB-11417-203, an Ongoing, Phase 2 Study of Sonrotoclax (BGB-11417), a Next-Generation BCL2 Inhibitor, in Patients With Waldenström Macroglobulinemia","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Waldenstrom macroglobulinemia; Macroglobulinemia; Ibrutinib; Medicine; Immunology; Leukemia; Multiple myeloma; Lymphoma; Chronic lymphocytic leukemia","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004558145,0.0003621961,0.0005781609,0.0004404139,0.00007741962,0.0001222088,0.0002335546,0.0001909211,0.0001743608],"category_scores_gemma":[0.0001334497,0.0002913569,0.00008624311,0.000861372,0.0001146508,0.0003636094,0.0001331639,0.0004887643,0.00004771398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002618825,"about_ca_system_score_gemma":0.004266539,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001477601,"about_ca_topic_score_gemma":0.001186257,"domain_scores_codex":[0.9964092,0.0001636898,0.000747407,0.0008143001,0.00126029,0.0006051215],"domain_scores_gemma":[0.9983988,0.00008168702,0.0001189652,0.0008087115,0.0002743659,0.0003175114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.01535176,0.2407614,0.3733698,0.006584115,0.004409096,0.01495486,0.04475252,0.0006696582,0.1197677,0.0003976966,0.009743113,0.1692383],"study_design_scores_gemma":[0.7435868,0.05584951,0.02514143,0.003475968,0.002112258,0.0005378923,0.00405575,0.05922714,0.1011254,0.00005902396,0.002955055,0.001873728],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951119,0.0003092897,0.00001488888,0.00006792317,0.0001802272,0.003842365,0.00003740239,0.0001337094,0.0003022752],"genre_scores_gemma":[0.9979324,0.00001607481,0.0004406291,0.00006312383,0.0005703509,0.0003170765,0.0002309692,0.00009387168,0.0003355162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7282351,"threshold_uncertainty_score":0.9999539,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03512004748815195,"score_gpt":0.324881224338984,"score_spread":0.289761176850832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}