{"id":"W4405046554","doi":"10.1182/blood-2024-194612","title":"Subcutaneous Mosunetuzumab Leads to High Rates of Durable Responses, Low Rates of Cytokine Release Syndrome, and Non-Inferior Exposure Compared with Intravenous Administration in Patients with Relapsed/Refractory Follicular Lymphoma: Primary Analysis of a Pivotal Phase II","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Jewish General Hospital; Spinal Cord Injury BC; University of British Columbia","funders":"","keywords":"Medicine; Cytokine release syndrome; Refractory (planetary science); Cytokine; Internal medicine; Lymphoma; Gastroenterology; Surgery; Immunotherapy; Cancer; Chimeric antigen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001189142,0.0004712281,0.0009961098,0.0002302585,0.000159226,0.0006884686,0.0002896818,0.0003522451,0.001788701],"category_scores_gemma":[0.0007681293,0.0001975527,0.0007188682,0.000292335,0.0003017207,0.0003298655,0.0001636367,0.001201554,0.0003687216],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004996777,"about_ca_system_score_gemma":0.0005378418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002994496,"about_ca_topic_score_gemma":0.0009273709,"domain_scores_codex":[0.9995989,0.0001837721,0.00003000847,0.00006619583,0.00005269073,0.00006843115],"domain_scores_gemma":[0.9995092,0.0001084076,0.0001580487,0.0000603185,0.00003573405,0.0001283495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.400163,0.02581208,0.02128001,0.001365804,0.002132493,0.0002774676,0.0003122688,0.002697196,0.1951725,0.0002471312,0.004292695,0.3462474],"study_design_scores_gemma":[0.1858305,0.6749842,0.0770598,0.0001179777,0.002172743,0.001339699,0.0001366518,0.004015063,0.04572342,0.0002418044,0.008327394,0.00005070433],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939697,0.003208841,0.0007075632,0.0001297063,0.00003547962,0.000512333,0.000394914,0.00005131215,0.0009902667],"genre_scores_gemma":[0.9970773,0.0009344105,0.0006011596,0.0001318453,0.00004690052,0.000231613,0.0005056119,0.00001285872,0.0004583096],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001788701,"threshold_uncertainty_score":0.006288886,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005541275097004713,"score_gpt":0.2335532411583021,"score_spread":0.2280119660612973,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}