{"id":"W4405046626","doi":"10.1182/blood-2024-208893","title":"Ibrutinib in Elderly Patients with Chronic Lymphocytic Leukemia: Adverse Event Incidence, Management, and Outcome in a Canadian Real-World Setting","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Health Authority; Saskatchewan Health; Saskatchewan Cancer Agency; University of Saskatchewan","funders":"","keywords":"Ibrutinib; Medicine; Internal medicine; Discontinuation; Adverse effect; Chronic lymphocytic leukemia; Neutropenia; Fludarabine; Rash; Oncology; Leukemia; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001001906,0.0002767082,0.0003002761,0.001231473,0.001321402,0.001029269,0.0006091804,0.0003064329,0.001292753],"category_scores_gemma":[0.00267661,0.0001943736,0.0004962086,0.003932205,0.0004069812,0.0004073203,0.0008324689,0.0005619901,0.0001926403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01417518,"about_ca_system_score_gemma":0.01581368,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.8643252,"about_ca_topic_score_gemma":0.9185222,"domain_scores_codex":[0.9990261,0.0001185493,0.0001219583,0.0001506493,0.0003114808,0.0002713537],"domain_scores_gemma":[0.9962462,0.000178887,0.001521616,0.00008893117,0.001302748,0.0006617428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00009745346,0.00003236752,0.9946461,0.00005322504,0.00005692461,0.0001212474,0.0002262262,0.00005948184,0.00007468938,0.00003977333,0.0009387202,0.00365368],"study_design_scores_gemma":[0.00002535424,0.00006992689,0.9966313,0.00006598773,0.00005056941,0.0003058105,0.001095047,0.0002184831,0.00005572783,0.00002273828,0.001445715,0.00001328463],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906081,0.001805042,0.0001044978,0.0004713849,0.00001327601,0.00009432536,0.004638442,0.00000858032,0.002256389],"genre_scores_gemma":[0.995095,0.001503602,0.0002359604,0.00035703,0.00002652395,0.0000444815,0.002436911,0.000003593402,0.000296928],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8643252,"threshold_uncertainty_score":0.2729475,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00995485069152188,"score_gpt":0.2813056238684706,"score_spread":0.2713507731769488,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}