{"id":"W4405047042","doi":"10.1182/blood-2024-209646","title":"Alberta Cellular and Immunotherapy (ACIT) 001, Updated Results of Decentralized Production of Second Generation, Anti-CD19/41BB/CD3z Chimeric Antigen Receptor (CAR) T-Cells in Relapsed/Refractory (R/R) Acute Lymphoblastic Leukemia (ALL) and Aggressive Non-Hodgkin Lymphoma (NHL)","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Stollery Children's Hospital; University of Calgary; University of Alberta","funders":"","keywords":"Chimeric antigen receptor; Medicine; Immunotherapy; Refractory (planetary science); Cancer research; CD19; Blinatumomab; Hematologic Neoplasms; Antigen; Internal medicine; Immunology; Oncology; Cancer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00328432,0.0007856974,0.0007009816,0.0008481094,0.0004157028,0.001137041,0.0009762457,0.0008904061,0.002042186],"category_scores_gemma":[0.001048981,0.0002889087,0.0005127193,0.000794174,0.0004007962,0.0002583237,0.0003667481,0.001257683,0.000478487],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002565303,"about_ca_system_score_gemma":0.00366751,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02528067,"about_ca_topic_score_gemma":0.05319383,"domain_scores_codex":[0.9986464,0.0004654092,0.00005805076,0.0001280948,0.0005460984,0.0001559095],"domain_scores_gemma":[0.9987832,0.000188006,0.0002490794,0.0001040706,0.000312269,0.0003633206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.04537611,0.01418778,0.02463125,0.001556166,0.0009839584,0.001041394,0.0003248261,0.01331714,0.2677512,0.001786486,0.1227217,0.506322],"study_design_scores_gemma":[0.04652406,0.1856603,0.1679109,0.0002542265,0.002932739,0.002937521,0.0001764944,0.005949503,0.2039421,0.001281373,0.3822817,0.0001491653],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8165638,0.04774826,0.01277649,0.005839859,0.00119532,0.009144974,0.04170541,0.001354011,0.06367174],"genre_scores_gemma":[0.8660306,0.0144268,0.01976813,0.004367918,0.0005744274,0.002192655,0.06751464,0.0002483398,0.02487648],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02528067,"threshold_uncertainty_score":0.05026704,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01019333480851342,"score_gpt":0.2535019991890671,"score_spread":0.2433086643805537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}