{"id":"W4405047455","doi":"10.1182/blood-2024-208842","title":"Immune and Tumor Mediators of Resistance to Daratumumab-IMiDs Based Therapies in Relapsed Multiple Myeloma","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Daratumumab; Pomalidomide; Lenalidomide; CD38; Multiple myeloma; Cancer research; Immune system; Immunology; Medicine; Internal medicine; Biology; Oncology; CD34; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000288979,0.0001603512,0.0003453355,0.0005684017,0.0001518105,0.0004166376,0.0001426606,0.0001822361,0.001106014],"category_scores_gemma":[0.0002167587,0.00008615899,0.0001597344,0.0003948603,0.0001559874,0.0001263405,0.0001999239,0.0002990875,0.0002542623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002418959,"about_ca_system_score_gemma":0.00014244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003711218,"about_ca_topic_score_gemma":0.0005481398,"domain_scores_codex":[0.9998503,0.00002161204,0.00001099566,0.0000372143,0.00005229502,0.00002756117],"domain_scores_gemma":[0.9999098,0.0000171884,0.00002942592,0.00000750551,0.00001700825,0.00001903622],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004455633,0.0002496834,0.3107952,0.0003284842,0.0001416263,0.0005486259,0.0004598798,0.001146589,0.599233,0.0001324038,0.0006590616,0.08184968],"study_design_scores_gemma":[0.00006446263,0.002100039,0.8910109,0.00003174295,0.0002165238,0.001847898,0.0003341853,0.002883476,0.09674838,0.0002161328,0.004532942,0.00001342977],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979675,0.001149761,0.0002958673,0.00002467275,0.000003413248,0.00001028985,0.000302395,0.00001664856,0.0002293265],"genre_scores_gemma":[0.9975369,0.0005580933,0.0006647486,0.00004460851,0.00001142195,0.00002344198,0.0007077687,0.000008472151,0.0004444874],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001106014,"threshold_uncertainty_score":0.003700018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01263497566653678,"score_gpt":0.2741708648999122,"score_spread":0.2615358892333754,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}