{"id":"W4405047501","doi":"10.1182/blood-2024-203718","title":"A Phase 1, Single Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Subcutaneously Administered SRSD107 in Healthy Subjects","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Medicine; Tolerability; Pharmacodynamics; Hemostasis; Thrombosis; Pharmacokinetics; Pharmacology; Deep vein; Stroke (engine); Internal medicine; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001918478,0.002263072,0.003184889,0.0005663651,0.0007068679,0.0007251546,0.000934572,0.002199374,0.007727399],"category_scores_gemma":[0.0008992879,0.0007615475,0.001082917,0.0003177889,0.001331035,0.001010751,0.0002695429,0.003041486,0.001607925],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005530701,"about_ca_system_score_gemma":0.001494193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005890945,"about_ca_topic_score_gemma":0.001201289,"domain_scores_codex":[0.9993685,0.0002406314,0.00003733768,0.0001510195,0.00008569435,0.0001169637],"domain_scores_gemma":[0.99911,0.0001542889,0.000178355,0.00009566524,0.0001033849,0.0003583344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7123477,0.1537767,0.001851124,0.00100005,0.0009236106,0.0002360798,0.0001963485,0.0007053859,0.08710103,0.0001933983,0.003374751,0.03829383],"study_design_scores_gemma":[0.3174418,0.6727492,0.003272852,0.00001549267,0.0002754642,0.0001134622,0.00003251421,0.0003972908,0.004300477,0.00008849547,0.001292112,0.00002100952],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847675,0.002223362,0.001613439,0.0005155429,0.0003571237,0.00692768,0.00132083,0.0002677355,0.002006849],"genre_scores_gemma":[0.9730786,0.001841771,0.004620564,0.001800399,0.0004810594,0.007681045,0.001975741,0.00006748292,0.008453292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007727399,"threshold_uncertainty_score":0.02585065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04040964652404151,"score_gpt":0.3691233701450055,"score_spread":0.328713723620964,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}