{"id":"W4405047663","doi":"10.1182/blood-2024-211815","title":"Development of a UM171-Supported, CD33 Epitope-Engineered Blood Stem Cell Graft for Advanced AML Therapies","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Research in Immunology and Cancer; Université de Montréal","funders":"","keywords":"Stem cell; Epitope; CD33; Medicine; Peripheral Blood Stem Cells; Immunology; Internal medicine; Transplantation; Biology; Hematopoietic stem cell transplantation; Antibody; CD34; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000132132,0.0002544047,0.0002012725,0.0001855629,0.0001077807,0.0003909734,0.0002297543,0.0002642668,0.001593609],"category_scores_gemma":[0.00008152655,0.000104681,0.0001542143,0.0001276572,0.0001105534,0.00017598,0.0001918865,0.0005274698,0.000548907],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002416677,"about_ca_system_score_gemma":0.0002806933,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003086757,"about_ca_topic_score_gemma":0.000419146,"domain_scores_codex":[0.9999231,0.000007921443,0.000005628357,0.00001441892,0.0000302908,0.00001861091],"domain_scores_gemma":[0.9999545,0.000004064041,0.0000151012,0.000004004477,0.000005676056,0.00001664783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008141875,0.00005114939,0.0001185335,0.00002664855,0.000003918534,0.00004046604,0.00001437856,0.0002758804,0.995152,0.0004100685,0.0001214782,0.003704186],"study_design_scores_gemma":[0.00001445242,0.0003174919,0.0004665142,0.000003960995,0.00001200991,0.0001304339,0.000008144939,0.001455404,0.9927586,0.00003745904,0.004792863,0.000002756955],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.979809,0.0009743395,0.0147201,0.0001502546,0.00007107536,0.0001801708,0.0006586665,0.0002258292,0.003210512],"genre_scores_gemma":[0.9827524,0.0008198858,0.0118136,0.00008107044,0.00001068418,0.00009492623,0.0008903753,0.00005056228,0.003486547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001593609,"threshold_uncertainty_score":0.005331218,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01012231774109724,"score_gpt":0.2322276785770876,"score_spread":0.2221053608359904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}