{"id":"W4405047874","doi":"10.1182/blood-2024-193368","title":"Results from the Hemophilia Α Cohort of the Non-Investigational Lead-in Study: Prospective Collection of Bleeding Rate in Participants with Hemophilia Α Prior to Phase 3 Study (AFFINE) of Giroctocogene Fitelparvovec","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pfizer (Canada); McMaster University; Thrombosis and Atherosclerosis Research Institute","funders":"","keywords":"Medicine; Clinical endpoint; Clinical trial; Prospective cohort study; Hemarthrosis; Internal medicine; Cohort; Phases of clinical research; Pediatrics; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004033564,0.0006045172,0.0006454262,0.0004256506,0.0005927899,0.001334184,0.0005280859,0.0006378043,0.003998552],"category_scores_gemma":[0.006551168,0.0003630697,0.0008334038,0.00067234,0.0003237789,0.0005244171,0.0005482595,0.001163411,0.000979956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004394439,"about_ca_system_score_gemma":0.001088469,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001476981,"about_ca_topic_score_gemma":0.002597959,"domain_scores_codex":[0.9975736,0.001053898,0.0002346468,0.0003907597,0.0005763294,0.0001708931],"domain_scores_gemma":[0.9952739,0.0007286367,0.001711553,0.0006002715,0.0009015328,0.0007840867],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1865448,0.005151108,0.7448105,0.0007946538,0.002979118,0.000401361,0.0008545746,0.0003538294,0.005181646,0.0005512057,0.01396797,0.03840913],"study_design_scores_gemma":[0.02971961,0.03783289,0.9108741,0.0002754308,0.002475057,0.001504386,0.0005240433,0.0004862479,0.002029758,0.0004473732,0.01374842,0.00008260614],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9660203,0.001683692,0.001513754,0.0004388413,0.0000905906,0.00400029,0.01914982,0.00007610791,0.007026492],"genre_scores_gemma":[0.9777364,0.0005904568,0.001446657,0.000631594,0.000120244,0.002649497,0.01435809,0.00003709225,0.002429823],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004033564,"threshold_uncertainty_score":0.02133179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04122781204670945,"score_gpt":0.3353218732716381,"score_spread":0.2940940612249286,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}