{"id":"W4405049511","doi":"10.1182/blood-2024-200268","title":"A Phase 1/2 Study of Nuvisertib (TP-3654), an Investigational Selective PIM1 Kinase Inhibitor, in Combination with JAK Inhibitors Ruxolitinib or Momelotinib in Patients with Myelofibrosis","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Cancer Mechanisms and Therapy","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Ruxolitinib; Myelofibrosis; Medicine; Tofacitinib; Phases of clinical research; Janus kinase inhibitor; Pharmacology; Investigational Drugs; Internal medicine; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001987956,0.0002358358,0.0003928359,0.0004908884,0.0000387442,0.00003203082,0.00006556431,0.00007954895,0.00005111589],"category_scores_gemma":[0.00003455535,0.0001708829,0.00002969569,0.001280866,0.00006281346,0.0002808071,0.00001944072,0.0002487413,0.000002314446],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001278112,"about_ca_system_score_gemma":0.0004577357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005360123,"about_ca_topic_score_gemma":0.001433899,"domain_scores_codex":[0.9982039,0.00008807104,0.0004368956,0.0004626164,0.0005576604,0.0002508354],"domain_scores_gemma":[0.9992588,0.00005529854,0.0001100876,0.0002083476,0.0002237958,0.000143689],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01532319,0.09397756,0.8435341,0.0004993952,0.0004407857,0.0002928417,0.02178977,0.00004705597,0.01326579,0.00111876,0.00005436709,0.009656413],"study_design_scores_gemma":[0.1587332,0.09423481,0.6395978,0.00238662,0.0003435218,0.00001686977,0.003016477,0.0003870998,0.1001663,0.0005132252,0.00005829486,0.0005458069],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979123,0.00005192894,0.00001198941,0.00007816221,0.00007968481,0.001705466,0.00003749708,0.00005013214,0.00007286236],"genre_scores_gemma":[0.9990717,0.000003437599,0.0003661005,0.00007037725,0.00007511945,0.0002097724,0.0001072948,0.00005244648,0.00004376159],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2039363,"threshold_uncertainty_score":0.6968402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01300474013605575,"score_gpt":0.2724617725301055,"score_spread":0.2594570323940497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}