{"id":"W4405050041","doi":"10.1182/blood-2024-201855","title":"Long-Term Outcomes and Adverse Events of CAR T-19 Cell Therapy in Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia - a Systematic Review and Meta-Analysis","year":2024,"lang":"en","type":"review","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Adverse effect; Meta-analysis; Lymphoblastic Leukemia; Oncology; Refractory (planetary science); Leukemia; CAR T-cell therapy; Acute lymphocytic leukemia; Internal medicine; Cancer; Chimeric antigen receptor; Biology; Immunotherapy","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01194934,0.002760077,0.01924201,0.006861643,0.0006281898,0.003300215,0.00222193,0.002593586,0.003503906],"category_scores_gemma":[0.03112792,0.00160639,0.0444415,0.007647177,0.0006493092,0.001607447,0.001505954,0.001606682,0.0002991904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003188257,"about_ca_system_score_gemma":0.004158275,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0083554,"about_ca_topic_score_gemma":0.01547915,"domain_scores_codex":[0.9909339,0.004316915,0.002636048,0.0008664163,0.0009243554,0.0003223504],"domain_scores_gemma":[0.9855129,0.01011608,0.002451741,0.0004501307,0.001271193,0.0001979888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.001268487,0.00002402859,0.001892803,0.5005735,0.4861766,0.0001267656,0.00006817615,0.0006447461,0.0001803907,0.0001378718,0.0005703778,0.008336174],"study_design_scores_gemma":[0.000419323,0.0001634895,0.00202909,0.03273984,0.9626613,0.00008363673,0.00003581155,0.0001753317,0.00009056111,0.0001758683,0.001400814,0.00002502014],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003221079,0.9951284,0.0003799563,0.0001560932,0.0001149005,0.0002654141,0.0005304382,0.00001857015,0.000185238],"genre_scores_gemma":[0.1147351,0.8792459,0.00187277,0.000897462,0.0002540458,0.001738056,0.0009277794,0.00002569023,0.0003031211],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01924201,"threshold_uncertainty_score":0.06319493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08288058284013552,"score_gpt":0.3791185913339176,"score_spread":0.2962380084937821,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}