{"id":"W4405050054","doi":"10.1182/blood-2024-206915","title":"Clinical Outcomes over 2 Years of Once-Weekly Efanesoctocog Alfa Treatment in Children with Severe Hemophilia A: Second Interim Analysis from the Phase 3 XTEND-ed Long-Term Extension Study","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; Novo Nordisk; CSL Behring; Swedish Orphan Biovitrum; Canadian Hemophilia Society; Genentech","keywords":"Interim; Medicine; Interim analysis; Pediatrics; Term (time); Clinical trial; Internal medicine; History","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009044826,0.001563425,0.002793748,0.0005994784,0.0006722929,0.001768699,0.0008351071,0.001491208,0.00412315],"category_scores_gemma":[0.005616728,0.0005805594,0.005226199,0.0006027708,0.0006204253,0.001457101,0.0009125267,0.003514959,0.0008014613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009298384,"about_ca_system_score_gemma":0.001740398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001024737,"about_ca_topic_score_gemma":0.001294572,"domain_scores_codex":[0.9971586,0.001187487,0.0002256171,0.0003912917,0.0004754329,0.0005614274],"domain_scores_gemma":[0.9934723,0.001508298,0.002432197,0.0006914635,0.0008708251,0.001024941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7837253,0.01209103,0.1056006,0.001820719,0.0127979,0.0003970871,0.0003824228,0.004843483,0.004855172,0.0004449592,0.01516587,0.05787553],"study_design_scores_gemma":[0.1984015,0.3745244,0.3863912,0.0004554586,0.01707497,0.001076249,0.0003218388,0.002873568,0.00468067,0.0008382562,0.01313364,0.000228394],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9628142,0.005808228,0.001817165,0.0006475272,0.0002282618,0.003027774,0.02086528,0.0002001658,0.004591457],"genre_scores_gemma":[0.9640241,0.001192701,0.002164851,0.0009108743,0.0002479063,0.005687481,0.02320415,0.00004835919,0.00251962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009044826,"threshold_uncertainty_score":0.04783416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04113550274078684,"score_gpt":0.3918125394095262,"score_spread":0.3506770366687393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}