{"id":"W4405050191","doi":"10.1182/blood-2024-208861","title":"ULTRA FRAIL-MM Clinical Trial: Go-Slow Approach Incorporating Isatuximab, Lenalidomide and Dexamethasone for Ultra-Frail Newly Diagnosed Myeloma","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Lenalidomide; Dexamethasone; Multiple myeloma; Medicine; Carfilzomib; Internal medicine; Oncology; Pomalidomide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001498532,0.0008803089,0.001346101,0.0003455062,0.0002806072,0.00113714,0.0005852454,0.0009601598,0.005735753],"category_scores_gemma":[0.0008135476,0.000188636,0.001612918,0.0003752171,0.0005341377,0.0005219723,0.0006064383,0.002007536,0.0008784307],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006678744,"about_ca_system_score_gemma":0.001207375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000859982,"about_ca_topic_score_gemma":0.002069894,"domain_scores_codex":[0.9996388,0.0001531399,0.0000219448,0.00006834141,0.00005240407,0.00006531907],"domain_scores_gemma":[0.9995852,0.00005620516,0.00007537963,0.00003364608,0.00003121232,0.0002182524],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7896723,0.007355291,0.005342489,0.002346887,0.002532138,0.0001744167,0.00011467,0.001632323,0.00705601,0.00139382,0.01241662,0.1699631],"study_design_scores_gemma":[0.8758875,0.09409533,0.01364252,0.0003296919,0.0009692891,0.0001744117,0.00002839189,0.0008221567,0.0008118479,0.0006157315,0.01258451,0.00003868163],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9427076,0.0242641,0.001226853,0.003788911,0.001131695,0.005806495,0.004673693,0.0003471867,0.01605355],"genre_scores_gemma":[0.9576183,0.006694637,0.00359047,0.005613531,0.0007682176,0.006303909,0.006806242,0.00005217683,0.01255262],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005735753,"threshold_uncertainty_score":0.01918799,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08088941607811272,"score_gpt":0.3670511888249458,"score_spread":0.286161772746833,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}