{"id":"W4405050440","doi":"10.1182/blood-2024-204116","title":"Expansion of <i>GATA1</i>-Mutant Clones in Blood Samples of Patients with Transient Abnormal Myelopoiesis (TAM) during Clinical Follow up Heralds Transformation to Myeloid Leukemia Associated with Down Syndrome (ML-DS)","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; SickKids Foundation; Hospital for Sick Children","funders":"","keywords":"GATA1; Myelopoiesis; Myeloid; Myeloid leukemia; Transformation (genetics); Leukemia; Medicine; Mutant; Mutation; Biology; Cancer research; Immunology; Internal medicine; Genetics; Erythropoiesis; Haematopoiesis; Gene; Anemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001399294,0.0001738694,0.0001731582,0.001022154,0.0003038427,0.0003317581,0.0002142985,0.0002752028,0.001025087],"category_scores_gemma":[0.0006928345,0.0001264216,0.0001001501,0.0004555388,0.0002371202,0.000119522,0.0001897232,0.0002407285,0.0002889027],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001537838,"about_ca_system_score_gemma":0.0001000317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008358701,"about_ca_topic_score_gemma":0.00115081,"domain_scores_codex":[0.9998006,0.00002479851,0.00002993141,0.00006614828,0.00004592899,0.00003260023],"domain_scores_gemma":[0.9997148,0.00009479887,0.0000657158,0.00002534433,0.00004301844,0.00005640383],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001358391,0.00009204187,0.6251943,0.0001259474,0.00004348318,0.01184882,0.001229274,0.0001280568,0.3413567,0.0001686866,0.0004852442,0.01796907],"study_design_scores_gemma":[0.00002733895,0.0005992788,0.9018804,0.0000313616,0.00005768726,0.03916837,0.0006188326,0.0003652173,0.05383894,0.00006836846,0.003335341,0.000008811424],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977887,0.0005660152,0.000456893,0.00002886945,0.000006206826,0.0000263835,0.0004536248,0.00002173815,0.0006515569],"genre_scores_gemma":[0.9973239,0.0002855061,0.001035387,0.00005747579,0.0000109017,0.00002215847,0.0008929326,0.00001012489,0.0003616402],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001025087,"threshold_uncertainty_score":0.003429234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01631984082915015,"score_gpt":0.2658330986708299,"score_spread":0.2495132578416797,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}