{"id":"W4405052961","doi":"10.1182/blood-2024-194331","title":"Glofitamab in Combination with R-ICE Chemoimmunotherapy or as Monotherapy in Children and Adolescents with Relapsed/Refractory B-cell non-Hodgkin Lymphoma: Initial Safety and Efficacy Results from the Ongoing iMATRIX-GLO Study","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"","keywords":"Medicine; Chemoimmunotherapy; Internal medicine; Rituximab; Cohort; Oncology; Lymphoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008005381,0.0003634967,0.001256382,0.0002215919,0.000155998,0.0005829441,0.0003692014,0.0004388248,0.001216635],"category_scores_gemma":[0.0007134512,0.0002259194,0.0009778501,0.000275485,0.0003796599,0.0005274286,0.0002797932,0.001724423,0.0003832083],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007055115,"about_ca_system_score_gemma":0.000691507,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008016163,"about_ca_topic_score_gemma":0.002781659,"domain_scores_codex":[0.9997459,0.00009810617,0.00002026038,0.00004309755,0.00003982961,0.00005276868],"domain_scores_gemma":[0.9993708,0.0001152651,0.0001832881,0.00004078272,0.0000383113,0.0002515503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3894347,0.01836627,0.1512165,0.001993673,0.004375053,0.001155237,0.0008871895,0.00275559,0.02938254,0.0004282632,0.009235102,0.3907698],"study_design_scores_gemma":[0.2209427,0.4412336,0.2937555,0.0006462131,0.004182797,0.003862797,0.0006847858,0.003418215,0.008345926,0.0004778581,0.02235932,0.00009036479],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904303,0.007644198,0.0001036765,0.0002530703,0.00003580166,0.0001586644,0.0005026558,0.00002943279,0.0008422743],"genre_scores_gemma":[0.9930507,0.004268579,0.0004198958,0.0004975086,0.00006091743,0.000201131,0.001103816,0.00001331512,0.000384093],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001256382,"threshold_uncertainty_score":0.005118847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009643382075257279,"score_gpt":0.2786636109654514,"score_spread":0.2690202288901941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}