{"id":"W4405054871","doi":"10.1182/blood-2024-207258","title":"Mondoa Promotes Resistance to Asparaginase Treatment in B-ALL By Inducing Asparagine Synthesis","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Plant tissue culture and regeneration","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Asparaginase; Asparagine; Biology; Chemistry; Cancer research; Medicine; Biochemistry; Leukemia; Genetics; Enzyme; Lymphoblastic Leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001461161,0.0002491688,0.0003002463,0.0002472232,0.0001535684,0.0004412477,0.0001846836,0.0002769085,0.00160353],"category_scores_gemma":[0.0001597003,0.0001037618,0.0003705831,0.0001473741,0.0001938062,0.0001774969,0.0002536079,0.0005835026,0.0003269662],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002484747,"about_ca_system_score_gemma":0.000160276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003709269,"about_ca_topic_score_gemma":0.0004758099,"domain_scores_codex":[0.9998558,0.00002147821,0.00001807154,0.00002656696,0.00004363574,0.00003445228],"domain_scores_gemma":[0.9999001,0.00001259899,0.00003426258,0.00001074788,0.00001305583,0.00002927862],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000254978,0.00004802895,0.0008968832,0.0001055117,0.00001096051,0.00006394539,0.00002147435,0.0000699618,0.9948995,0.00008873569,0.0001513236,0.003388776],"study_design_scores_gemma":[0.00003658141,0.00077841,0.01573804,0.00002024405,0.00004782792,0.0005917879,0.0001066429,0.0008622053,0.9707465,0.00008352506,0.01097869,0.000009602418],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886755,0.005139973,0.002946452,0.0002551103,0.00007007549,0.00004423413,0.0008619593,0.0002579525,0.001748676],"genre_scores_gemma":[0.9944224,0.001370417,0.001778202,0.00009527271,0.000008752922,0.00004564866,0.0008628141,0.00002110232,0.001395341],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00160353,"threshold_uncertainty_score":0.005364418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01419975209886796,"score_gpt":0.2527324516780273,"score_spread":0.2385326995791593,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}