{"id":"W4405062908","doi":"10.1007/s13346-024-01746-z","title":"In vitro tear replenishment system: assessing drug delivery from contact lens biomaterials through corneal epithelial monolayer and multilayer under replenishment conditions","year":2024,"lang":"en","type":"article","venue":"Drug Delivery and Translational Research","topic":"Ocular Surface and Contact Lens","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Latanoprost; Contact lens; Drug delivery; Biomedical engineering; Monolayer; Chemistry; Cornea; In vivo; In vitro; Corneal epithelium; Ophthalmology; Materials science; Nanotechnology; Glaucoma; Medicine; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004673545,0.0005067842,0.0003066068,0.0002848032,0.0002474303,0.0004212941,0.0002418652,0.0003969923,0.0006321552],"category_scores_gemma":[0.0003110203,0.0002134715,0.0003553813,0.0002857148,0.0001655689,0.0005000493,0.0002402124,0.0004280819,0.0001775893],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003309456,"about_ca_system_score_gemma":0.0002076648,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002164605,"about_ca_topic_score_gemma":0.002370916,"domain_scores_codex":[0.999617,0.00007332928,0.00007103563,0.00006401892,0.0001344106,0.00004019206],"domain_scores_gemma":[0.9996789,0.0000843166,0.00008660975,0.00004114412,0.00008183749,0.00002717513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005130234,0.0000234605,0.0003320572,0.00004313582,0.000004443158,0.00002484264,0.00003298942,0.00005191084,0.9987555,0.000008157446,0.000006090262,0.000666204],"study_design_scores_gemma":[0.000005608565,0.0007458177,0.005234006,0.000006281936,0.00002803801,0.0001023792,0.0000595847,0.001174606,0.9920813,0.000009849367,0.0005451289,0.000007411331],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893591,0.001886524,0.007704871,0.00003301685,0.00001640434,0.00007514281,0.0002844527,0.00007805281,0.0005624535],"genre_scores_gemma":[0.9818981,0.001607834,0.0143512,0.00005224054,0.000007995349,0.0001233261,0.0004806468,0.00002697144,0.001451807],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002164605,"threshold_uncertainty_score":0.004303992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05737148112555675,"score_gpt":0.3552806333672356,"score_spread":0.2979091522416789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}