{"id":"W4405062908","doi":"10.1007/s13346-024-01746-z","title":"In vitro tear replenishment system: assessing drug delivery from contact lens biomaterials through corneal epithelial monolayer and multilayer under replenishment conditions","year":2024,"lang":"en","type":"article","venue":"Drug Delivery and Translational Research","topic":"Ocular Surface and Contact Lens","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Latanoprost; Contact lens; Drug delivery; Biomedical engineering; Monolayer; Chemistry; Cornea; In vivo; In vitro; Corneal epithelium; Ophthalmology; Materials science; Nanotechnology; Glaucoma; Medicine; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00129572,0.0002700143,0.0004616806,0.0003039906,0.0003567779,0.000347488,0.00008905056,0.0001559173,0.0002004687],"category_scores_gemma":[0.00002332497,0.0002426741,0.0001252367,0.000264908,0.0001400982,0.0009527305,0.00006546298,0.0004158338,0.00006888645],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001876915,"about_ca_system_score_gemma":0.0005064191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004482159,"about_ca_topic_score_gemma":0.0002457731,"domain_scores_codex":[0.9967452,0.0004377626,0.000572218,0.0007887476,0.0008773851,0.0005786858],"domain_scores_gemma":[0.9982455,0.001001621,0.00004790838,0.0002908522,0.0002195632,0.0001944948],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001608067,0.0003074695,0.008132235,0.0006616995,0.000560861,0.001077596,0.004214021,0.00003009723,0.9779395,0.003074455,0.0005439445,0.00185002],"study_design_scores_gemma":[0.01405381,0.0004405902,0.2003051,0.005420311,0.00095591,0.0002584343,0.01609938,0.02933263,0.7027293,0.007269113,0.02151421,0.001621208],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987996,0.00584312,0.00009620732,0.003570095,0.0002973696,0.0008321138,0.000754699,0.00008938536,0.0005209672],"genre_scores_gemma":[0.9972169,0.0009999749,0.0006133414,0.0002485394,0.0002514998,0.00007715927,0.0003720033,0.00004281584,0.0001777725],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2752103,"threshold_uncertainty_score":0.9895962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05737148112555675,"score_gpt":0.3552806333672356,"score_spread":0.2979091522416789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}