{"id":"W4405072342","doi":"10.3389/fcell.2024.1496884","title":"Molecular and metabolomic characterization of hiPSC-derived cardiac fibroblasts transitioning to myofibroblasts","year":2024,"lang":"en","type":"article","venue":"Frontiers in Cell and Developmental Biology","topic":"Cardiac Fibrosis and Remodeling","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary; Simon Fraser University; University of Manitoba; St. Boniface Hospital; University of British Columbia; BC Children's Hospital","funders":"Canadian Institutes of Health Research; BC Children's Hospital; Michael Smith Health Research BC; Stem Cell Network; Children's Hospital Foundation; Heart and Stroke Foundation of Canada","keywords":"Myofibroblast; Metabolomics; Cell biology; Chemistry; Computational biology; Biology; Fibrosis; Medicine; Bioinformatics; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001074132,0.0001212231,0.0003549235,0.0002212077,0.00002722158,0.00001310304,0.00002011729,0.0001060926,0.00000538357],"category_scores_gemma":[0.000005575223,0.0001059906,0.00005375092,0.0001592693,0.00006234566,0.00004552228,0.00003834958,0.00008212992,0.000002065128],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000364984,"about_ca_system_score_gemma":0.00005329093,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008362889,"about_ca_topic_score_gemma":3.683068e-7,"domain_scores_codex":[0.9992474,0.0000348036,0.00022897,0.0002793718,0.00005211123,0.0001573582],"domain_scores_gemma":[0.9998246,0.00001483653,0.00002019089,0.00004609403,0.00001712237,0.00007711196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001023626,0.00001014903,0.007264263,0.0002021361,0.0000554804,0.000004024375,0.0008868657,0.000007079389,0.978265,0.00002671453,0.00007357347,0.0131023],"study_design_scores_gemma":[0.0007945991,0.0002221872,0.07587445,0.0005703892,0.00009017718,0.00003855387,0.0006895369,0.001069707,0.916775,0.0001227241,0.003460052,0.0002925795],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824675,0.003085459,0.0133044,0.0001471939,0.0004249185,0.0002316365,0.00002997767,0.00002043705,0.0002884856],"genre_scores_gemma":[0.9741319,0.000584879,0.02497972,0.00009136408,0.00002585937,0.00001015676,0.0001187533,0.0000137274,0.000043595],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06861018,"threshold_uncertainty_score":0.4322172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005726893022147884,"score_gpt":0.213864260762217,"score_spread":0.2081373677400692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}