{"id":"W4405072342","doi":"10.3389/fcell.2024.1496884","title":"Molecular and metabolomic characterization of hiPSC-derived cardiac fibroblasts transitioning to myofibroblasts","year":2024,"lang":"en","type":"article","venue":"Frontiers in Cell and Developmental Biology","topic":"Cardiac Fibrosis and Remodeling","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary; Simon Fraser University; University of Manitoba; St. Boniface Hospital; University of British Columbia; BC Children's Hospital","funders":"Canadian Institutes of Health Research; BC Children's Hospital; Michael Smith Health Research BC; Stem Cell Network; Children's Hospital Foundation; Heart and Stroke Foundation of Canada","keywords":"Myofibroblast; Metabolomics; Cell biology; Chemistry; Computational biology; Biology; Fibrosis; Medicine; Bioinformatics; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009643381,0.0002555051,0.0002085923,0.0005686979,0.0001725365,0.000240826,0.00009573325,0.0001714226,0.0007245427],"category_scores_gemma":[0.00009984897,0.00007146296,0.0002500539,0.0004977374,0.0001236226,0.0001004433,0.0001330202,0.0002958933,0.0001888023],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001142848,"about_ca_system_score_gemma":0.0001697748,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001151242,"about_ca_topic_score_gemma":0.001732056,"domain_scores_codex":[0.9999249,0.000004641143,0.000005246815,0.00002152079,0.00003111844,0.00001256933],"domain_scores_gemma":[0.9999382,0.000007797658,0.00001423436,0.000004238947,0.00002254305,0.00001296877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005744146,0.000008029097,0.0006104799,0.00002483218,0.000006255285,0.00005384851,0.00001247751,0.00003577567,0.9981274,0.0000131069,0.00002245233,0.0010278],"study_design_scores_gemma":[0.00001568822,0.0003475644,0.08585441,0.00002184451,0.0001013453,0.0005528093,0.0001690443,0.001365464,0.9085249,0.00009179069,0.002932091,0.00002292033],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9800132,0.003044929,0.006979852,0.00007943065,0.00003315791,0.00009430141,0.008087965,0.00007939112,0.001587827],"genre_scores_gemma":[0.9612212,0.003422998,0.01744103,0.0002063366,0.00002593519,0.0002822708,0.0131808,0.00005929053,0.004160149],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001151242,"threshold_uncertainty_score":0.002423882,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005726893022147884,"score_gpt":0.213864260762217,"score_spread":0.2081373677400692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}