{"id":"W4405096089","doi":"10.1182/blood-2024-205727","title":"Topic Modeling of Genotyping of Transcriptomes Reveals Collaboration between BTKC481S-Mutant and Wild Type Cells in Btki-Resistant Chronic Lymphocytic Leukemia","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Chronic lymphocytic leukemia; Genotyping; Mutant; Biology; Transcriptome; Leukemia; Genetics; Cancer research; Molecular biology; Genotype; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005035597,0.0003488957,0.000434346,0.000215317,0.0001950332,0.0006301387,0.0004704198,0.0005135576,0.0005379313],"category_scores_gemma":[0.001284643,0.0002749568,0.0006432238,0.0002462066,0.0003613729,0.0002839554,0.000357662,0.0003103355,0.00009234185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005519473,"about_ca_system_score_gemma":0.0004177534,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009276121,"about_ca_topic_score_gemma":0.005982627,"domain_scores_codex":[0.999858,0.00003990841,0.000005265563,0.0000540259,0.00001289933,0.00002994086],"domain_scores_gemma":[0.9994794,0.000350885,0.00006357997,0.00003332787,0.00003401695,0.00003876912],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"observational","study_design_scores_codex":[0.0001163309,0.00004062733,0.02977684,0.00002172139,0.00005321352,0.0001005802,0.00006557033,0.9578446,0.008147405,0.0007376934,0.0001332026,0.002962407],"study_design_scores_gemma":[0.000003586164,0.00001696573,0.005739208,0.000001046083,0.000009789296,0.00001159514,0.00001746113,0.9931825,0.000531621,0.000397779,0.00008425581,0.000004176755],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888667,0.00005825856,0.01039391,0.00005050155,0.000003710038,0.000006299375,0.0002166249,0.00004854005,0.0003553558],"genre_scores_gemma":[0.9963193,0.0000460138,0.002655505,0.0000155327,0.000004051117,0.00002572966,0.0005072529,0.00001941764,0.0004072993],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009276121,"threshold_uncertainty_score":0.01844424,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02120031658623975,"score_gpt":0.2911469645347938,"score_spread":0.269946647948554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}