{"id":"W4405096089","doi":"10.1182/blood-2024-205727","title":"Topic Modeling of Genotyping of Transcriptomes Reveals Collaboration between BTKC481S-Mutant and Wild Type Cells in Btki-Resistant Chronic Lymphocytic Leukemia","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Chronic lymphocytic leukemia; Genotyping; Mutant; Biology; Transcriptome; Leukemia; Genetics; Cancer research; Molecular biology; Genotype; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004823094,0.0001802687,0.0005946414,0.0003433617,0.0000295427,0.00002640078,0.0001503696,0.0001664247,0.00002509469],"category_scores_gemma":[0.0001248687,0.0001636443,0.00007111787,0.000891115,0.0001003041,0.0001141298,0.0000619895,0.0001837943,0.000005293537],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.0119226,"about_ca_system_score_gemma":0.01721839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009248823,"about_ca_topic_score_gemma":0.0001167242,"domain_scores_codex":[0.9980922,0.00006702864,0.0006865685,0.0003692331,0.0004423847,0.0003426376],"domain_scores_gemma":[0.9990695,0.0001694929,0.00007148779,0.0004187424,0.0001627588,0.0001080407],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002706392,0.00007081235,0.000682954,0.006763574,0.0003480416,0.0001838467,0.002162074,0.003149563,0.9843284,0.0003827239,0.00003899417,0.001618306],"study_design_scores_gemma":[0.03295604,0.001202529,0.001304849,0.006389508,0.001163407,0.00009842247,0.0006705291,0.4730138,0.4814435,0.0009318179,0.0003623001,0.000463289],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9806077,0.01820214,0.0001273589,0.00007138086,0.00009778598,0.0005465622,0.00003173672,0.00004121487,0.0002740706],"genre_scores_gemma":[0.9978201,0.001325838,0.000469416,0.00001442616,0.0001499184,0.00001245915,0.00001758617,0.00003727218,0.0001529182],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5028849,"threshold_uncertainty_score":0.9918705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02120031658623975,"score_gpt":0.2911469645347938,"score_spread":0.269946647948554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}