{"id":"W4405105103","doi":"10.1021/acs.biochem.4c00624","title":"HutZ from <i>Aliivibrio fischeri</i> Inhibits HutW-Mediated Anaerobilin Formation by Sequestering Heme","year":2024,"lang":"en","type":"article","venue":"Biochemistry","topic":"Porphyrin Metabolism and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Okanagan University College; University of British Columbia, Okanagan Campus; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Heme; Operon; Escherichia coli; Biochemistry; Protoporphyrin IX; Fusobacterium nucleatum; Biology; Heme oxygenase; Chemistry; Cytotoxicity; Microbiology; Stereochemistry; Bacteria; Gene; Enzyme; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001190199,0.0002504747,0.0001605678,0.0000249592,0.00005791703,0.000108548,0.0002068656,0.0002919871,0.00006807861],"category_scores_gemma":[0.00007587548,0.0002556621,0.0001167537,0.0001351644,0.00006858353,0.00001902891,0.0001348955,0.0001353085,0.00006899878],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002196709,"about_ca_system_score_gemma":0.00008994305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004697477,"about_ca_topic_score_gemma":0.000006679298,"domain_scores_codex":[0.9987139,0.00002675466,0.0002841564,0.0005104127,0.0001618746,0.0003029211],"domain_scores_gemma":[0.9993724,0.00001435461,0.00005966868,0.0003831621,0.0000373742,0.0001330273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002754346,0.00002936864,0.0001815244,0.00008820435,0.00003666928,0.000005000201,0.00003385611,0.000003219148,0.967283,0.000003387519,0.03094839,0.001359832],"study_design_scores_gemma":[0.0002931744,0.00002889738,0.0000739731,0.00005260324,0.00002034204,0.000008389906,0.00006609586,0.0001782073,0.8886122,0.00003096288,0.1103475,0.0002877013],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9803287,0.0155829,0.001208276,0.0001677541,0.0002432986,0.0001127975,0.0005101503,0.0001078091,0.001738348],"genre_scores_gemma":[0.9914012,0.0007319071,0.0003842868,0.0004517607,0.0004096762,0.00003321903,0.005490195,0.00004248193,0.001055252],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0793991,"threshold_uncertainty_score":0.9999896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00554001194722946,"score_gpt":0.2186761140933857,"score_spread":0.2131361021461562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}