{"id":"W4405119439","doi":"10.1016/j.aohep.2024.101599","title":"OP-1 LONG-TERM EFFICACY AND SAFETY OF OPEN-LABEL SELADELPAR TREATMENT IN PATIENTS WITH PRIMARY BILIARY CHOLANGITIS: INTERIM 2-YEAR RESULTS FROM THE ASSURE STUDY","year":2024,"lang":"en","type":"article","venue":"Annals of Hepatology","topic":"Gallbladder and Bile Duct Disorders","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Liver Centre","funders":"","keywords":"Medicine; Interim; Interim analysis; Open label; Term (time); Internal medicine; Surgery; Gastroenterology; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004216067,0.0005654409,0.001761042,0.0003172425,0.000349326,0.001062589,0.0005035623,0.001112643,0.007489887],"category_scores_gemma":[0.00235715,0.0002937753,0.00191809,0.0003099343,0.0004659231,0.0009159519,0.0003561828,0.00249091,0.001370027],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003409428,"about_ca_system_score_gemma":0.0006316316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002645865,"about_ca_topic_score_gemma":0.0008295521,"domain_scores_codex":[0.9989429,0.0005328901,0.00008080239,0.00008491616,0.0002156908,0.0001427383],"domain_scores_gemma":[0.9971426,0.0007545544,0.0009326723,0.0002865088,0.0002987691,0.0005849592],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7677462,0.01342232,0.02407486,0.002103608,0.004029546,0.0002903852,0.0001839503,0.0009997213,0.01256467,0.0005548247,0.0294174,0.1446126],"study_design_scores_gemma":[0.3567747,0.4564684,0.1528056,0.000356652,0.00386303,0.0007225045,0.000181421,0.001464541,0.005821276,0.0007835057,0.02066769,0.00009058861],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9483196,0.01541214,0.001705539,0.003025019,0.0005563718,0.002142205,0.01684204,0.0003141228,0.01168299],"genre_scores_gemma":[0.9648401,0.004048196,0.002652013,0.003490984,0.001096825,0.001874108,0.01599635,0.00006466395,0.005936926],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007489887,"threshold_uncertainty_score":0.02505618,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05681497674420066,"score_gpt":0.3471924872448938,"score_spread":0.2903775105006932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}