{"id":"W4405119439","doi":"10.1016/j.aohep.2024.101599","title":"OP-1 LONG-TERM EFFICACY AND SAFETY OF OPEN-LABEL SELADELPAR TREATMENT IN PATIENTS WITH PRIMARY BILIARY CHOLANGITIS: INTERIM 2-YEAR RESULTS FROM THE ASSURE STUDY","year":2024,"lang":"en","type":"article","venue":"Annals of Hepatology","topic":"Gallbladder and Bile Duct Disorders","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Liver Centre","funders":"","keywords":"Medicine; Interim; Interim analysis; Open label; Term (time); Internal medicine; Surgery; Gastroenterology; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002335233,0.0001724812,0.000554187,0.00009550776,0.00002559765,0.00001749032,0.0001811628,0.00008261886,0.00002738002],"category_scores_gemma":[0.00006476097,0.00009874741,0.00003361911,0.0001926436,0.0001490211,0.00009849706,0.0001392497,0.000153396,0.00000380158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001847894,"about_ca_system_score_gemma":0.0001326014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001159863,"about_ca_topic_score_gemma":0.0005890524,"domain_scores_codex":[0.9986312,0.0001693004,0.0004572483,0.0003824886,0.000168512,0.0001912572],"domain_scores_gemma":[0.9990886,0.0002846249,0.00009235623,0.0003859729,0.00009435642,0.00005410368],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007298952,0.003911154,0.9737242,0.00006884165,0.0006760737,0.0001102191,0.002374846,4.305517e-7,0.00005105648,0.00001034127,0.001049543,0.01072436],"study_design_scores_gemma":[0.01409472,0.005304398,0.9792202,0.0002964502,0.0001779206,0.000007606285,0.0003747951,0.000008013183,0.0001407289,0.00002037063,0.0002617707,0.00009309],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936611,0.001712936,0.000001049881,0.002406872,0.00007480349,0.001453612,0.000227472,0.00001630345,0.0004458657],"genre_scores_gemma":[0.9987274,0.0005122155,0.00004246517,0.0003232902,0.00001669057,0.00002603106,0.0002932664,0.00001866563,0.00003998352],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01063127,"threshold_uncertainty_score":0.4026802,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05681497674420066,"score_gpt":0.3471924872448938,"score_spread":0.2903775105006932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}